{"id":"W2014782873","doi":"10.1016/j.ccr.2012.04.036","title":"ID1 and ID3 Regulate the Self-Renewal Capacity of Human Colon Cancer-Initiating Cells through p21","year":2012,"lang":"en","type":"article","venue":"Cancer Cell","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Ontario Ministry of Health and Long-Term Care; Ontario Institute for Cancer Research; Cancer Research Institute; Ontario Genomics Institute; Princess Margaret Hospital Foundation; Canadian Institutes of Health Research; Genome Canada","keywords":"Colorectal cancer; Cancer; Cancer research; Cancer cell; Biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131112,0.0001250631,0.0001200804,0.000008253228,0.0001174881,0.0000114464,0.0001000592,0.0001119209,0.00006984493],"category_scores_gemma":[0.00000275093,0.0001036614,0.00005240866,0.00004680101,0.0001094453,0.00001449797,0.00003285871,0.00006415552,0.000001107671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000439548,"about_ca_system_score_gemma":0.00004061016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001018777,"about_ca_topic_score_gemma":0.0005652356,"domain_scores_codex":[0.9992614,0.00006087131,0.0001765878,0.0001802031,0.0001046577,0.0002162249],"domain_scores_gemma":[0.9995263,0.000008662088,0.0001391813,0.0002116853,0.00006340072,0.00005080594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001611569,0.00003115443,0.006615437,0.00006737583,0.00003257556,6.186115e-8,0.000873644,0.00006186333,0.9915759,0.0001005221,0.0004144445,0.0002108949],"study_design_scores_gemma":[0.0004042927,0.00006584565,0.008372387,0.00001667455,0.00005271684,9.004235e-7,0.00009437682,0.00002140794,0.9813973,0.00004694265,0.009396621,0.0001305223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938697,0.003826169,0.0000561078,0.00006707899,0.0003228993,0.0001737514,0.00005589605,0.00001266842,0.001615711],"genre_scores_gemma":[0.9984422,0.0006491632,0.0001822343,0.0001257213,0.0003052111,0.00003036336,0.00002502126,0.00001842838,0.0002216615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0101786,"threshold_uncertainty_score":0.422719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02713459081574593,"score_gpt":0.2725609234730983,"score_spread":0.2454263326573524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}