{"id":"W2014801535","doi":"10.1074/jbc.m102754200","title":"Cooperative Regulation of the Invasive and Metastatic Phenotypes by Different Domains of the Type I Insulin-like Growth Factor Receptor β Subunit","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital; McGill University Health Centre","funders":"Shriners Hospitals for Children","keywords":"Biology; Insulin-like growth factor 1 receptor; Receptor; Receptor tyrosine kinase; Tyrosine kinase; Transfection; Growth factor; Phenotype; Cell biology; Insulin-like growth factor; Molecular biology; Growth factor receptor; Signal transduction; Cell culture; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001143165,0.00023746,0.0001741525,0.0001301628,0.00007315069,0.0002495357,0.0001188944,0.000133537,0.0004512248],"category_scores_gemma":[0.0001283538,0.000165463,0.0002244459,0.00007011219,0.0001964363,0.0001110572,0.0002471947,0.0003377319,0.0001855775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001479462,"about_ca_system_score_gemma":0.0001271182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003623938,"about_ca_topic_score_gemma":0.0004159089,"domain_scores_codex":[0.9998769,0.00001624954,0.00001064446,0.00001985967,0.00004312531,0.00003327486],"domain_scores_gemma":[0.9998386,0.00002858772,0.00004758011,0.00002201999,0.00001838426,0.00004482561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003365392,0.0000057295,0.0002299547,0.000003674921,0.000001112726,0.00001825674,0.000005620498,0.00001887601,0.9993881,0.00003058957,0.000003193235,0.0002613595],"study_design_scores_gemma":[0.00001745812,0.0002552211,0.02649466,0.00000351227,0.00001494077,0.00047523,0.00005341767,0.001609165,0.9705133,0.00004693359,0.0005090054,0.000007129688],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998912,0.0001372761,0.0005705203,0.000008012451,0.00000223237,0.000004841502,0.00002284447,0.00001136466,0.0003308899],"genre_scores_gemma":[0.9983536,0.0001654011,0.0006802085,0.00001299681,0.000001543744,0.000009995894,0.00009746761,0.000007545909,0.0006713523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004512248,"threshold_uncertainty_score":0.001509547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02595571598181258,"score_gpt":0.2450805231106765,"score_spread":0.2191248071288639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}