{"id":"W2014862652","doi":"10.1158/1538-7445.prca2012-b14","title":"Abstract B14: Developing small-molecule inhibitors to the androgen receptor N-terminus domain for the treatment of advanced prostate cancer","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Androgen receptor; Prostate cancer; Antiandrogens; Intracrine; Transactivation; Cancer research; Medicine; Androgen; Cancer; Internal medicine; Pharmacology; Endocrinology; Receptor; Chemistry; Transcription factor; Hormone; Biochemistry; Paracrine signalling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435162,0.0004337301,0.0002614445,0.0002341961,0.00009850821,0.0002148517,0.0003255966,0.0002427956,0.003141572],"category_scores_gemma":[0.00004828238,0.0001045974,0.0002742538,0.0001223126,0.0001207102,0.000149851,0.0001667788,0.0004925996,0.001122407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208652,"about_ca_system_score_gemma":0.0003855081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000533097,"about_ca_topic_score_gemma":0.0008483697,"domain_scores_codex":[0.9999664,0.000004393427,0.000002217073,0.000005451506,0.00001103624,0.00001045159],"domain_scores_gemma":[0.9999734,0.000002340145,0.00000466753,0.000001354393,0.000005288995,0.00001295098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001607256,0.0009747965,0.0006416262,0.0006923891,0.0001025085,0.0003237691,0.00003309097,0.001722966,0.866545,0.002170135,0.00501324,0.1201733],"study_design_scores_gemma":[0.003357642,0.02256721,0.01041021,0.0001575296,0.0002830421,0.002418183,0.00003751972,0.007889694,0.8133389,0.0008509888,0.1386186,0.00007050933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8689565,0.06528625,0.01974913,0.001150578,0.0008250083,0.001103535,0.002868657,0.0008090331,0.0392513],"genre_scores_gemma":[0.9175032,0.02952323,0.01223419,0.0007964592,0.00009667096,0.0003849479,0.003926195,0.0000511899,0.03548392],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003141572,"threshold_uncertainty_score":0.01050961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09851968613890107,"score_gpt":0.427689093179413,"score_spread":0.329169407040512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}