{"id":"W2014907409","doi":"10.1021/bi052054x","title":"Mechanistic Analysis of the Unusual Redox-Elimination Sequence Employed by <i>Thermotoga maritima </i>BglT:  A 6-Phospho-β-glucosidase from Glycoside Hydrolase Family 4","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Kinetic isotope effect; Leaving group; Stereochemistry; Oxocarbenium; Glycosidic bond; Deprotonation; Transition state; Elimination reaction; Concerted reaction; Crystallography; Deuterium; Enzyme; Nucleophile; Medicinal chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001908536,0.0004938145,0.0006140752,0.00005687298,0.0001967692,0.00007765534,0.0008953238,0.0004902136,0.001671387],"category_scores_gemma":[0.0003288991,0.0004584557,0.0006138091,0.0008093215,0.0002711328,0.0001058507,0.0002144175,0.0003780831,0.00001600503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003744194,"about_ca_system_score_gemma":0.0001656011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007130641,"about_ca_topic_score_gemma":0.00003414595,"domain_scores_codex":[0.9971712,0.00004196309,0.0007678466,0.0008604161,0.0006804442,0.0004781916],"domain_scores_gemma":[0.9973834,0.0003275935,0.0004902136,0.001403471,0.0001653346,0.0002300575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001323924,0.0002538422,0.0002623821,0.0001089238,0.000595581,0.00001520002,0.0001005266,0.00006707977,0.9956471,0.00001308416,0.001314839,0.001489072],"study_design_scores_gemma":[0.0005486929,0.000008084746,0.0001495115,0.000115374,0.001521056,0.000007206908,0.000274771,0.006952679,0.9891189,0.00009184437,0.0007253774,0.0004864626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896198,0.0006612401,0.0000997419,0.0003088731,0.00005008013,0.0000889474,0.003880081,0.0001179279,0.005173344],"genre_scores_gemma":[0.9959791,0.00005359139,0.000259631,0.0002192834,0.0001914184,0.00006820621,0.001274846,0.0000537557,0.001900116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0068856,"threshold_uncertainty_score":0.9997867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006695155332476,"score_gpt":0.2222938040036097,"score_spread":0.2122268524502849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}