{"id":"W2014917932","doi":"10.1161/circep.111.969733","title":"In Situ Confocal Imaging in Intact Heart Reveals Stress-Induced Ca <sup>2+</sup> Release Variability in a Murine Catecholaminergic Polymorphic Ventricular Tachycardia Model of Type 2 Ryanodine Receptor <sup>R4496C+/−</sup> Mutation","year":2012,"lang":"en","type":"article","venue":"Circulation Arrhythmia and Electrophysiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Fondation Leducq; American Heart Association","keywords":"Ryanodine receptor 2; Catecholaminergic polymorphic ventricular tachycardia; Ryanodine receptor; Myocyte; Internal medicine; Catecholaminergic; Endocrinology; Stimulation; Biology; Biophysics; Calcium; Medicine; Catecholamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893878,0.000355255,0.0002824159,0.0003113639,0.0002430189,0.000254265,0.0004063042,0.0006252409,0.001001877],"category_scores_gemma":[0.0001012835,0.0002346306,0.0002727315,0.000133412,0.0003251899,0.0003190259,0.0003117307,0.0006796184,0.0002976013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003257944,"about_ca_system_score_gemma":0.0001510706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008565827,"about_ca_topic_score_gemma":0.00141638,"domain_scores_codex":[0.999866,0.000008184871,0.00001019373,0.00005268093,0.00002637376,0.00003654144],"domain_scores_gemma":[0.999817,0.00002677745,0.00005815861,0.00002049175,0.00002814457,0.00004945177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003169505,0.000005582704,0.00008467997,0.000007232759,0.000001305148,0.00003976266,0.00001267564,0.00002219504,0.9996123,0.0000235687,0.00001062627,0.0001484739],"study_design_scores_gemma":[0.00002413871,0.0002292343,0.01659077,0.00000957684,0.00002383229,0.0006055195,0.00007352575,0.003119756,0.978462,0.00008594605,0.0007640094,0.00001173978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888005,0.0004061937,0.008943359,0.00008737158,0.00002401387,0.00002617058,0.0006347924,0.000124069,0.0009534776],"genre_scores_gemma":[0.979565,0.0005972148,0.01583962,0.00008403613,0.00002057513,0.0001236733,0.000758744,0.0001158928,0.002895156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001877,"threshold_uncertainty_score":0.003351569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102513759037967,"score_gpt":0.2512112316685043,"score_spread":0.2409598557647076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}