{"id":"W2014935444","doi":"10.1093/brain/awu043","title":"Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer’s disease and mild cognitive impairment","year":2014,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institutes of Health; Genentech; IXICO; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Synarc; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Medpace; AstraZeneca; Bristol-Myers Squibb; Eli Lilly and Company; Novartis Pharmaceuticals Corporation; F. Hoffmann-La Roche; Amorfix Life Sciences; Alzheimer's Drug Discovery Foundation; Foundation for the National Institutes of Health","keywords":"Cerebral blood flow; Dementia; Alzheimer's disease; Precuneus; Medicine; Positron emission tomography; Temporal cortex; Pathology; Magnetic resonance imaging; Neuroimaging; Amyloid (mycology); Cerebral cortex; Cardiology; Blood flow; Internal medicine; Psychology; Neuroscience; Disease; Functional magnetic resonance imaging; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004389076,0.0001244595,0.0002097125,0.0001388785,0.00004556861,0.00001932533,0.00002677584,0.00005679929,0.0001353724],"category_scores_gemma":[0.000314653,0.00009576722,0.00002414696,0.0001383582,0.00008422003,0.00007847459,0.00005361702,0.0001434659,0.000001625844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003702869,"about_ca_system_score_gemma":0.00006713144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006357657,"about_ca_topic_score_gemma":0.0001384957,"domain_scores_codex":[0.9988183,0.000169196,0.0001568677,0.000251981,0.0003695315,0.0002341038],"domain_scores_gemma":[0.9992709,0.0002791267,0.00007735784,0.00007827846,0.0001057864,0.0001885788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00116383,0.0001562061,0.9805962,0.0000828735,0.00009535559,0.00001252803,0.0005071616,3.0236e-7,0.001969305,0.00006022472,0.001041578,0.01431441],"study_design_scores_gemma":[0.006551661,0.001047214,0.9889935,0.0002676221,0.0001701883,0.000006646446,0.0003873795,0.0003923617,0.00162035,0.0002247971,0.0002318818,0.0001064403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913889,0.0002372728,0.00003677906,0.007166456,0.00001252904,0.0007067418,0.00004272856,0.00001162127,0.0003970004],"genre_scores_gemma":[0.9981435,0.00002131281,0.00008481158,0.001124685,0.00004390893,0.00001901529,0.00006634072,0.00001304312,0.0004834125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01420797,"threshold_uncertainty_score":0.3905274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009479485567402374,"score_gpt":0.2793973671263113,"score_spread":0.2699178815589089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}