{"id":"W2014935444","doi":"10.1093/brain/awu043","title":"Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer’s disease and mild cognitive impairment","year":2014,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institutes of Health; Genentech; IXICO; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Synarc; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Medpace; AstraZeneca; Bristol-Myers Squibb; Eli Lilly and Company; Novartis Pharmaceuticals Corporation; F. Hoffmann-La Roche; Amorfix Life Sciences; Alzheimer's Drug Discovery Foundation; Foundation for the National Institutes of Health","keywords":"Cerebral blood flow; Dementia; Alzheimer's disease; Precuneus; Medicine; Positron emission tomography; Temporal cortex; Pathology; Magnetic resonance imaging; Neuroimaging; Amyloid (mycology); Cerebral cortex; Cardiology; Blood flow; Internal medicine; Psychology; Neuroscience; Disease; Functional magnetic resonance imaging; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004879797,0.0003766659,0.0003760757,0.0009454884,0.0003581098,0.0003803674,0.0002478947,0.0004261985,0.0006344304],"category_scores_gemma":[0.001344732,0.0002900942,0.0003058428,0.0003906672,0.000507699,0.0002916277,0.0004775866,0.0003513843,0.0001298206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002670753,"about_ca_system_score_gemma":0.0001465922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004341982,"about_ca_topic_score_gemma":0.005017071,"domain_scores_codex":[0.9998162,0.00004630496,0.00002044547,0.00004704169,0.00003690767,0.00003297849],"domain_scores_gemma":[0.9993654,0.0001450918,0.0002635423,0.00004724856,0.00005428803,0.0001244463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001488139,0.0001993971,0.9910885,0.00002983368,0.0001683868,0.0003483591,0.0005033829,0.00009172592,0.003106908,0.00002649199,0.00005196382,0.00289685],"study_design_scores_gemma":[0.00001366817,0.0001208593,0.9994723,0.000001526771,0.00001307336,0.000174805,0.00004397721,0.00003948157,0.00007042628,0.00002488652,0.00002322709,0.000001718949],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997906,0.00009942138,0.00001472535,0.000005441759,8.776299e-7,0.000002002186,0.00001634183,7.788024e-7,0.00006982491],"genre_scores_gemma":[0.9997515,0.00005137128,0.00004776827,0.00001033156,0.000004400697,0.000004174188,0.00005428342,4.921983e-7,0.00007567101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004341982,"threshold_uncertainty_score":0.008633435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009479485567402374,"score_gpt":0.2793973671263113,"score_spread":0.2699178815589089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}