{"id":"W2014938747","doi":"10.1016/j.bmc.2007.03.055","title":"Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Quinazoline; Moiety; Kinase; Cysteine; Enzyme; Stereochemistry; Biochemistry; Docking (animal); Amide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005629156,0.0008046815,0.0005105403,0.0001925491,0.0001956741,0.0004432544,0.00105489,0.0007095064,0.001598504],"category_scores_gemma":[0.0001966651,0.0003200092,0.0002523342,0.0001505869,0.0004196901,0.0005921953,0.0003945623,0.0008082627,0.000468125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006527145,"about_ca_system_score_gemma":0.0002735336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00028638,"about_ca_topic_score_gemma":0.0005929295,"domain_scores_codex":[0.9997403,0.0000453485,0.00001158169,0.00007698694,0.00006838173,0.00005742404],"domain_scores_gemma":[0.999925,0.00001119802,0.00002338788,0.000009949361,0.00001165727,0.00001878402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003634414,0.00008044155,0.0001101061,0.0001706493,0.00002671024,0.0001016763,0.00002339818,0.0003841226,0.9851115,0.001634191,0.0003438993,0.01164994],"study_design_scores_gemma":[0.0004585129,0.00133197,0.0007636211,0.000013583,0.00007406328,0.0007444459,0.000008330069,0.002377848,0.9833104,0.0002706457,0.01061666,0.0000298346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.860323,0.0157903,0.1092115,0.0008872093,0.0003626498,0.0006676677,0.0004777236,0.00107705,0.0112028],"genre_scores_gemma":[0.970812,0.002907978,0.01992465,0.0002484942,0.00003895036,0.0001648464,0.0002548156,0.00002637839,0.005621863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001598504,"threshold_uncertainty_score":0.00534755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008816336832880809,"score_gpt":0.23518078924581,"score_spread":0.2263644524129292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}