{"id":"W2014969421","doi":"10.1371/journal.pone.0106766","title":"Synergistic Anti-Inflammatory Activity of the Antimicrobial Peptides Human Beta-Defensin-3 (hBD-3) and Cathelicidin (LL-37) in a Three-Dimensional Co-Culture Model of Gingival Epithelial Cells and Fibroblasts","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Beta defensin; Cathelicidin; Antimicrobial peptides; Aggregatibacter actinomycetemcomitans; Secretion; Lipopolysaccharide; Microbiology; Defensin; Antimicrobial; Chemistry; Cytotoxic T cell; Immune system; Biology; Immunology; Molecular biology; Porphyromonas gingivalis; In vitro; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000255644,0.0002754755,0.0006972964,0.00009107344,0.0002221926,0.00001471064,0.0001794645,0.0002647176,0.0000152812],"category_scores_gemma":[0.00004936961,0.0002109027,0.0001089646,0.00007440128,0.001034612,0.0001215723,0.0002240025,0.0003688818,0.000005993508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002058068,"about_ca_system_score_gemma":0.00005297266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002657168,"about_ca_topic_score_gemma":0.000203435,"domain_scores_codex":[0.9986627,0.0001748198,0.000390744,0.0003588519,0.00008739541,0.0003255529],"domain_scores_gemma":[0.9991086,0.0001637156,0.0003215018,0.0002912864,0.00008705335,0.00002791479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001454154,0.0005358865,0.003871603,0.0002931819,0.0001793709,8.756693e-7,0.0005058929,0.0003250232,0.9934468,0.0004535991,0.0001724148,0.00006991489],"study_design_scores_gemma":[0.001038419,0.0001465596,0.009019791,0.0005245437,0.0001419318,0.00000690596,0.00002153615,0.0007736504,0.9878726,0.0002167576,0.000009785073,0.0002275157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990303,0.0001113621,0.00003738504,0.00009355986,0.00005077532,0.0002906452,0.0002803251,0.00002201219,0.00008362841],"genre_scores_gemma":[0.9991881,0.00003892883,0.0002994184,0.00004746744,0.00003529241,0.000003468017,0.0000158173,0.00002648323,0.0003450362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005574218,"threshold_uncertainty_score":0.8600364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01840688951596786,"score_gpt":0.2056933052560023,"score_spread":0.1872864157400345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}