{"id":"W2014973711","doi":"10.1016/j.radonc.2011.08.013","title":"The receptor tyrosine kinase inhibitor amuvatinib (MP470) sensitizes tumor cells to radio- and chemo-therapies in part by inhibiting homologous recombination","year":2011,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Terry Fox Foundation; Ontario Ministry of Health and Long-Term Care","keywords":"Homologous recombination; Receptor tyrosine kinase; Tyrosine kinase; Cancer research; Homologous chromosome; Tyrosine-kinase inhibitor; Recombination; Cell biology; Chemistry; Receptor; Kinase; Medicine; Biology; Internal medicine; Biochemistry; Gene; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002827872,0.0003795913,0.0006717242,0.0004707553,0.0002529814,0.0007479506,0.0004531133,0.0006188281,0.002970986],"category_scores_gemma":[0.0003049381,0.0002326544,0.0003823849,0.0005676911,0.0003788681,0.0004545893,0.0003838331,0.001213128,0.001216278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004812844,"about_ca_system_score_gemma":0.000291319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003670739,"about_ca_topic_score_gemma":0.0005886242,"domain_scores_codex":[0.9997461,0.00004338077,0.0000211121,0.00005191944,0.00007787938,0.00005966648],"domain_scores_gemma":[0.9999115,0.00001902996,0.00003151466,0.00001406434,0.000009805016,0.00001416108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007887895,0.0001990035,0.0009786629,0.0004736268,0.0001085379,0.00026125,0.00004955251,0.001282969,0.908058,0.002423228,0.002155007,0.0832214],"study_design_scores_gemma":[0.0003681061,0.001802773,0.006078584,0.00001920112,0.00007842247,0.004127882,0.00005668022,0.002079959,0.9431398,0.001528886,0.04069087,0.00002877225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8911428,0.06017099,0.01593659,0.002962629,0.0003861865,0.000233361,0.001507862,0.001178791,0.02648077],"genre_scores_gemma":[0.9853194,0.008647344,0.002194274,0.0001644014,0.00003404639,0.00003660757,0.0005829002,0.00003674754,0.002984267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002970986,"threshold_uncertainty_score":0.009938955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093963304509986,"score_gpt":0.2804133283281839,"score_spread":0.259473695283084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}