{"id":"W2014988440","doi":"10.1006/jmbi.2001.4881","title":"Cholesterol, a modulator of membrane-associated aβ-fibrillogenesis and neurotoxicity","year":2001,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Hospital for Sick Children; University of Toronto","keywords":"Fibrillogenesis; Membrane fluidity; Membrane; Biophysics; Cholesterol; Fluorescence anisotropy; Chemistry; Diphenylhexatriene; Lipid bilayer; Fluorescence microscope; Vesicle; Cell membrane; Biochemistry; Cell biology; Fluorescence; Biology; Fibril","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017573,0.0003009593,0.0002895427,0.0003911831,0.0005421452,0.000589343,0.0002338389,0.0003540181,0.0007493586],"category_scores_gemma":[0.0003313051,0.0001517493,0.0001698949,0.0002253139,0.0003248667,0.000314197,0.0002927149,0.0004818531,0.000164031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004717011,"about_ca_system_score_gemma":0.0004070528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582973,"about_ca_topic_score_gemma":0.001599023,"domain_scores_codex":[0.9999213,0.00001907042,0.000008517562,0.000008566292,0.00001650232,0.00002609214],"domain_scores_gemma":[0.9998944,0.00002247649,0.00002544123,0.000009096653,0.00002217027,0.00002649567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006900705,0.0002425544,0.003057347,0.0004609271,0.00007690092,0.00220298,0.0002365546,0.0002234998,0.959971,0.003183363,0.0008324279,0.02261182],"study_design_scores_gemma":[0.0004220493,0.001829093,0.03375319,0.0000828374,0.0002541123,0.003599321,0.0004153664,0.0009240929,0.9417555,0.003770806,0.01316129,0.00003239023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615304,0.03181625,0.001065428,0.0008446072,0.0001428001,0.00004899695,0.0002068654,0.00004771773,0.004296856],"genre_scores_gemma":[0.9853126,0.01208123,0.0004714839,0.0001051828,0.0001013427,0.00001846861,0.000123328,0.000006679185,0.001779628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001582973,"threshold_uncertainty_score":0.003422439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02054927225424407,"score_gpt":0.3197408760518137,"score_spread":0.2991916037975696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}