{"id":"W2014989420","doi":"10.1074/jbc.m112.445668","title":"Dephosphorylation at a Conserved SP Motif Governs cAMP Sensitivity and Nuclear Localization of Class IIa Histone Deacetylases*","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Dephosphorylation; Nuclear transport; Nuclear localization sequence; HDAC4; Nuclear export signal; Biology; Histone deacetylase 5; Histone deacetylase; Cell biology; Histone; Nuclear protein; NLS; Biochemistry; Cell nucleus; Transcription factor; Gene; Phosphatase; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264074,0.0001733609,0.0001523264,0.0001363847,0.0001443525,0.0002743717,0.0001658027,0.0001720558,0.001186386],"category_scores_gemma":[0.0001787441,0.0001486343,0.0001658843,0.00008548692,0.0002843769,0.0001331831,0.0001950648,0.0003589229,0.0003093775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003413489,"about_ca_system_score_gemma":0.0001566399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007814774,"about_ca_topic_score_gemma":0.001575031,"domain_scores_codex":[0.9998764,0.00001688779,0.00001075946,0.00002809215,0.00002587077,0.00004198856],"domain_scores_gemma":[0.9998839,0.00003116414,0.00003050645,0.00001557015,0.00001027734,0.00002855147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008426081,0.000007483973,0.0002574607,0.00001411035,0.000002753305,0.00002550105,0.000004534535,0.0000280685,0.9989145,0.00005937547,0.00001042034,0.0005915195],"study_design_scores_gemma":[0.000009655384,0.0001170765,0.01017613,0.000004267851,0.000009061195,0.0001757746,0.00002423359,0.0005572127,0.9880894,0.00007116736,0.0007626487,0.000003332286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955689,0.001432547,0.001124933,0.00006809355,0.0000203199,0.00001198736,0.0001249551,0.00002168325,0.001626694],"genre_scores_gemma":[0.9981003,0.0004680373,0.0005649895,0.00002306242,0.000007724567,0.000009821252,0.0001389862,0.000007195832,0.0006797865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001186386,"threshold_uncertainty_score":0.003968835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300364777359536,"score_gpt":0.2498115569149598,"score_spread":0.2368079091413645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}