{"id":"W2015044111","doi":"10.1073/pnas.1013170108","title":"Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institutes of Health; National Institute on Deafness and Other Communication Disorders; March of Dimes Foundation","keywords":"Convergent extension; Wnt signaling pathway; Frizzled; Gastrulation; Cell biology; Zebrafish; Cell polarity; LRP6; Biology; LRP5; PDZ domain; Signal transduction; Chemistry; Cell; Genetics; Gene; Embryo; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072693,0.0004288408,0.0001964462,0.0002490173,0.000364814,0.0003762017,0.0002974731,0.0002681728,0.001618971],"category_scores_gemma":[0.0001436356,0.0002705963,0.0002161187,0.00009953896,0.0002707359,0.0001816764,0.0002430214,0.0004814523,0.0006708736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007529182,"about_ca_system_score_gemma":0.0004772403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002096705,"about_ca_topic_score_gemma":0.003528626,"domain_scores_codex":[0.9997895,0.00002615674,0.00001750529,0.00005191075,0.00005867456,0.00005629712],"domain_scores_gemma":[0.9998546,0.00001286643,0.00004971451,0.00001402048,0.00001538881,0.00005339548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005307524,0.000006848911,0.0001890391,0.00001834982,0.000002518356,0.00006085158,0.000007550886,0.00004256122,0.9990512,0.0001188146,0.00002890666,0.0004203864],"study_design_scores_gemma":[0.0000173183,0.000046542,0.01108841,0.000007515058,0.00001650689,0.0005690051,0.00003493442,0.001411849,0.9828936,0.00007068061,0.003836877,0.000006672033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943768,0.001413362,0.001608537,0.0001622485,0.0000253041,0.00001247089,0.0004079699,0.0001378198,0.001855648],"genre_scores_gemma":[0.9953761,0.0003498585,0.0009127108,0.00003073206,0.000005022255,0.00001418881,0.000524308,0.00003499377,0.002752085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002096705,"threshold_uncertainty_score":0.005462766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06302524009865229,"score_gpt":0.2901720779202717,"score_spread":0.2271468378216194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}