{"id":"W2015057757","doi":"10.1073/pnas.1311495110","title":"Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Force spectroscopy; Chemistry; Cooperativity; Protein folding; Molecular dynamics; Folding (DSP implementation); Villin; Microsecond; Downhill folding; Crystallography; Spectroscopy; Chemical physics; Molecule; Phi value analysis; Computational chemistry; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002406427,0.00006826019,0.0001221011,0.00006720346,0.00006895983,0.0000223912,0.0002730228,0.00002828373,0.00002088491],"category_scores_gemma":[0.00002333053,0.00005009958,0.00003132783,0.0004124066,0.0004463126,0.0002077675,0.0000672155,0.00008905759,2.991867e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001216973,"about_ca_system_score_gemma":0.00001056628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004616574,"about_ca_topic_score_gemma":1.229084e-7,"domain_scores_codex":[0.9992652,0.000002761731,0.0002372656,0.0001440429,0.0002435781,0.0001071805],"domain_scores_gemma":[0.9995688,0.00004506611,0.0002257318,0.000007664371,0.0001337735,0.00001897031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000001211836,0.0000568399,0.01009076,0.00001386492,0.00000244549,1.52644e-10,0.00006759875,0.00002744845,0.9210338,0.06853403,0.00006756419,0.0001044419],"study_design_scores_gemma":[0.00007681781,0.00004480296,0.009655601,0.00006106025,0.000002887847,3.28158e-7,0.0001254746,0.0008314077,0.9592308,0.02990122,0.00002187885,0.00004775825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930605,0.00001846023,0.0001116481,0.0008151159,0.000002588157,0.0002267416,0.00001386427,0.000004341925,0.0057468],"genre_scores_gemma":[0.9940479,0.000004516462,0.005821445,0.00003611072,0.00001937733,0.00001879681,2.028505e-7,0.000002970951,0.00004865052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03863282,"threshold_uncertainty_score":0.2043002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02088062784691986,"score_gpt":0.2964064791274303,"score_spread":0.2755258512805104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}