{"id":"W2015060528","doi":"10.1165/rcmb.2009-0211oc","title":"STAT3, p38 MAPK, and NF-κB Drive Unopposed Monocyte-Dependent Fibroblast MMP-1 Secretion in Tuberculosis","year":2009,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute for Health and Care Research; Wellcome Trust","keywords":"Fibroblast; Secretion; Matrix metalloproteinase; Molecular biology; Kinase; Protein kinase A; Oncostatin M; Monocyte; MAPK/ERK pathway; Zymography; p38 mitogen-activated protein kinases; Biology; Chemistry; Cytokine; Cell biology; In vitro; Immunology; Endocrinology; Interleukin 6; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001900507,0.000317982,0.000226584,0.0001765622,0.0002043954,0.0002716716,0.0001367978,0.000250345,0.002989132],"category_scores_gemma":[0.0001115673,0.0002204468,0.0003621218,0.0001390655,0.0002775444,0.0001212875,0.0001881864,0.0006272335,0.0008278555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002351618,"about_ca_system_score_gemma":0.0002765275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006881446,"about_ca_topic_score_gemma":0.0009356153,"domain_scores_codex":[0.9997963,0.0000320068,0.00001885504,0.00002555547,0.00005584629,0.00007139336],"domain_scores_gemma":[0.9999094,0.00001159389,0.00001917063,0.0000104347,0.000008464114,0.00004085878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005870766,0.0001019912,0.0005141129,0.00004805029,0.000003417864,0.00008531655,0.00002557354,0.00003071021,0.9975213,0.00007315106,0.00006751523,0.0009417089],"study_design_scores_gemma":[0.0001951918,0.001603124,0.0305318,0.00002384797,0.00003937367,0.001314609,0.0001638302,0.002119958,0.9594325,0.0002211286,0.004345195,0.000009406648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960372,0.001322014,0.00104496,0.0001094732,0.00004874639,0.00002055591,0.0003627881,0.00006358795,0.0009906808],"genre_scores_gemma":[0.9955675,0.0004724363,0.0007979192,0.00005196724,0.0000130264,0.00004655773,0.0004491479,0.00001095495,0.002590456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002989132,"threshold_uncertainty_score":0.009999692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054531536707376,"score_gpt":0.2982177510310694,"score_spread":0.2876724356639956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}