{"id":"W2015060528","doi":"10.1165/rcmb.2009-0211oc","title":"STAT3, p38 MAPK, and NF-κB Drive Unopposed Monocyte-Dependent Fibroblast MMP-1 Secretion in Tuberculosis","year":2009,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute for Health and Care Research; Wellcome Trust","keywords":"Fibroblast; Secretion; Matrix metalloproteinase; Molecular biology; Kinase; Protein kinase A; Oncostatin M; Monocyte; MAPK/ERK pathway; Zymography; p38 mitogen-activated protein kinases; Biology; Chemistry; Cytokine; Cell biology; In vitro; Immunology; Endocrinology; Interleukin 6; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007172469,0.0002165309,0.0007341912,0.0004425827,0.00004684739,0.00001291786,0.0001057425,0.000140989,0.00002049238],"category_scores_gemma":[0.000200356,0.0001708519,0.0001162576,0.000225953,0.0004340106,0.0000601937,0.00005018291,0.000516822,0.000003928332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007865855,"about_ca_system_score_gemma":0.0001503589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008718841,"about_ca_topic_score_gemma":0.00001660833,"domain_scores_codex":[0.9978151,0.0006518014,0.0005879556,0.0003299633,0.0001584974,0.0004566476],"domain_scores_gemma":[0.9987811,0.0001456583,0.0003157397,0.0001870137,0.0001378419,0.0004325735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001158583,0.0001464366,0.03452788,0.00002960243,0.00009926155,0.0005369526,0.0001682798,0.00002849054,0.8973977,0.000135849,0.0002839209,0.06548703],"study_design_scores_gemma":[0.02017056,0.1024205,0.3967957,0.0006873236,0.0005203875,0.0030216,0.003819526,0.0006369521,0.4101715,0.003828618,0.05628904,0.001638191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920979,0.003656849,0.001234899,0.002382782,0.00003472558,0.0001799613,0.000007095818,0.000008905503,0.000396891],"genre_scores_gemma":[0.991699,0.001650897,0.001181667,0.005353461,0.0000731347,0.000003285186,0.000006983155,0.00001535795,0.00001623809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4872262,"threshold_uncertainty_score":0.696714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054531536707376,"score_gpt":0.2982177510310694,"score_spread":0.2876724356639956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}