{"id":"W2015114981","doi":"10.1182/blood-2010-07-294447","title":"Thrombospondin-1 is not the major activator of TGF-β1 in thrombopoietin-induced myelofibrosis","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Association pour la Recherche sur le Cancer","keywords":"Myelofibrosis; Thrombopoietin; Megakaryocyte; Bone marrow; Thrombospondin 1; Spleen; Platelet; Cytokine; Transforming growth factor; Thrombospondin; Fibrosis; Immunology; Activator (genetics); Internal medicine; Biology; Medicine; Cancer research; Endocrinology; Haematopoiesis; Angiogenesis; Cell biology; Receptor; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516145,0.000189441,0.0002031459,0.0002101943,0.00008981371,0.0001760639,0.00009036075,0.0002450924,0.00057813],"category_scores_gemma":[0.0001533935,0.0001125315,0.00008922265,0.00008492532,0.0002436562,0.0001299361,0.0001266153,0.0003929386,0.0001473004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000903424,"about_ca_system_score_gemma":0.00008468255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007374652,"about_ca_topic_score_gemma":0.0001172225,"domain_scores_codex":[0.9999243,0.00001863559,0.000008090326,0.00001269895,0.00002469605,0.00001158327],"domain_scores_gemma":[0.9998909,0.00001836002,0.00004180677,0.00001019339,0.000007385522,0.00003124754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003518675,0.0000393249,0.001944477,0.00002867692,0.000004153999,0.000294049,0.00001507501,0.00002577085,0.9952359,0.0001085948,0.00002048439,0.001931682],"study_design_scores_gemma":[0.0001341743,0.001641383,0.04392691,0.00001889916,0.00007606287,0.00835393,0.00005403736,0.0008582189,0.9419352,0.0002247609,0.002770354,0.000006024117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980137,0.0009305486,0.0006005072,0.00003410528,0.000004367441,0.00000789485,0.00003361744,0.000008476079,0.0003666307],"genre_scores_gemma":[0.9985358,0.0005025712,0.0004400759,0.00002321934,0.000008464732,0.0000104806,0.00009787217,0.000002956126,0.0003786594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00057813,"threshold_uncertainty_score":0.001934052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995763821873273,"score_gpt":0.2813375255812673,"score_spread":0.2613798873625346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}