{"id":"W2015137678","doi":"10.1039/c4nr00595c","title":"Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies","year":2014,"lang":"en","type":"article","venue":"Nanoscale","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Irish Research Council; Science Foundation Ireland; Irish Research Council for Science, Engineering and Technology","keywords":"Single-domain antibody; Epidermal growth factor receptor; Receptor; In vivo; Antibody; Computational biology; Epidermal growth factor; Biology; In vitro; Cell biology; Chemistry; Molecular biology; Biochemistry; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002906272,0.0001164233,0.0002946313,0.00006280033,0.0001488535,0.000009998509,0.0001343415,0.00007451365,0.0003484073],"category_scores_gemma":[0.0009334618,0.00007196113,0.0001111692,0.0002796823,0.0004524651,0.00003646823,0.0001271471,0.0001704195,0.00003224934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004090828,"about_ca_system_score_gemma":0.00003631909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001562236,"about_ca_topic_score_gemma":0.00003191936,"domain_scores_codex":[0.9986818,0.0002038639,0.0003257846,0.000191866,0.0002631384,0.0003335222],"domain_scores_gemma":[0.9989098,0.0006797113,0.00007536645,0.0001690987,0.00007787341,0.00008810827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004129693,0.0002158746,0.3366898,0.0000367264,0.000009229671,0.000003228744,0.000102951,0.00001492706,0.6614212,0.0005421882,0.0007355773,0.0001869717],"study_design_scores_gemma":[0.001206084,0.0004301384,0.6559216,0.0002781798,0.00002237479,0.00003034132,0.000290614,0.001770633,0.3257299,0.001073469,0.01306355,0.0001831388],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967793,0.000207676,0.00004242929,0.001595598,0.0001035198,0.0002697466,0.00003918401,0.00001795885,0.0009446124],"genre_scores_gemma":[0.9980049,0.00002161604,0.001377146,0.0002607745,0.0001181777,0.00000814968,0.00003251348,0.00001042941,0.0001662667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3356914,"threshold_uncertainty_score":0.3814815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06238249518973241,"score_gpt":0.3241542289145076,"score_spread":0.2617717337247751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}