{"id":"W2015167979","doi":"10.1021/ac901371n","title":"Unlabeled Hairpin DNA Probe for Electrochemical Detection of Single-Nucleotide Mismatches Based on MutS−DNA Interactions","year":2009,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Chinese Academy of Sciences","keywords":"Chemistry; DNA; Nucleotide; Duplex (building); Linker; Oligonucleotide; Hybridization probe; Biophysics; Molecular biology; Biochemistry; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005786182,0.0004924524,0.0003563717,0.0004175979,0.0001738485,0.0003145081,0.0007330687,0.001001923,0.001556247],"category_scores_gemma":[0.0006002188,0.0002422264,0.0001852611,0.000236446,0.0003256164,0.0005118679,0.0003025589,0.0009733713,0.0006329215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000263695,"about_ca_system_score_gemma":0.0001461374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001319668,"about_ca_topic_score_gemma":0.0004091185,"domain_scores_codex":[0.9992731,0.0001810974,0.00003375251,0.000170869,0.0002998441,0.00004132708],"domain_scores_gemma":[0.9996668,0.000160202,0.00004561434,0.00002546804,0.00006501735,0.00003683795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002798955,0.00001604225,0.00007764976,0.00005021427,0.000004334529,0.00002836297,0.00001861214,0.00004421655,0.9956082,0.0002708114,0.00005384714,0.003799637],"study_design_scores_gemma":[0.000006621694,0.0001733964,0.0002810573,0.000003626483,0.00001044953,0.000229832,0.000009145637,0.001759191,0.9955451,0.0001370495,0.001836842,0.000007622033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4646772,0.007303162,0.5194591,0.0007855428,0.0005201882,0.0002911291,0.000375967,0.001721217,0.004866583],"genre_scores_gemma":[0.697704,0.001978251,0.2905129,0.0006249773,0.0001271606,0.0001668671,0.0004163807,0.00005655515,0.008412809],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001556247,"threshold_uncertainty_score":0.005206168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016081818491317,"score_gpt":0.2674031616409379,"score_spread":0.2572423434560247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}