{"id":"W2015167979","doi":"10.1021/ac901371n","title":"Unlabeled Hairpin DNA Probe for Electrochemical Detection of Single-Nucleotide Mismatches Based on MutS−DNA Interactions","year":2009,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Chinese Academy of Sciences","keywords":"Chemistry; DNA; Nucleotide; Duplex (building); Linker; Oligonucleotide; Hybridization probe; Biophysics; Molecular biology; Biochemistry; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087787,0.0002241293,0.0002722116,0.00004310353,0.00007393966,0.00001853301,0.0001495812,0.0002239721,0.000004532925],"category_scores_gemma":[0.0003140962,0.0002077282,0.000299902,0.0001789852,0.0001090396,0.000004913933,0.00001971731,0.0001506327,9.24032e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005477758,"about_ca_system_score_gemma":0.00004385772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001312914,"about_ca_topic_score_gemma":0.000003541896,"domain_scores_codex":[0.9987414,0.00001856611,0.0003416556,0.0004571893,0.0001545206,0.0002866462],"domain_scores_gemma":[0.9991428,0.00004400295,0.0001455979,0.0003824978,0.000180614,0.0001044495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003211818,0.0003543865,0.00002027687,0.00003465664,0.0000518575,0.00000103833,0.000002541392,0.000005050089,0.997233,0.000007137409,0.0002702409,0.001698572],"study_design_scores_gemma":[0.0003811771,0.0004896475,0.00002998266,0.0000464014,0.0001083116,0.000006883704,0.00002000891,0.002923479,0.9933097,0.0002565144,0.002195892,0.0002319471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9351069,0.00004230038,0.06139186,0.001143476,0.00003119031,0.0002486534,0.00002458176,0.0001075133,0.001903488],"genre_scores_gemma":[0.9958557,0.000006440327,0.002961017,0.0002982857,0.0002236018,0.00001113585,0.0001731,0.00001915067,0.0004514997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06074883,"threshold_uncertainty_score":0.8470909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016081818491317,"score_gpt":0.2674031616409379,"score_spread":0.2572423434560247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}