{"id":"W2015184543","doi":"10.1016/j.jmb.2007.06.012","title":"The Folding Pathway of an FF domain: Characterization of an On-pathway Intermediate State Under Folding Conditions by 15N, 13Cα and 13C-methyl Relaxation Dispersion and 1H/2H-exchange NMR Spectroscopy","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Crystallography; Phi value analysis; Chemical shift; Folding (DSP implementation); Protein folding; Helix (gastropod); Downhill folding; Relaxation (psychology); Nuclear magnetic resonance spectroscopy; Helix bundle; Protein structure; Stereochemistry; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006723246,0.0001504629,0.0002263557,0.0001093442,0.0001013937,0.00001796899,0.0001362599,0.0001815024,0.000002383204],"category_scores_gemma":[0.00006959996,0.0001120094,0.00006652563,0.00007571709,0.0002024577,0.00002156613,0.00006314715,0.0001486823,8.187002e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002192495,"about_ca_system_score_gemma":0.00004196193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005389337,"about_ca_topic_score_gemma":0.00001749884,"domain_scores_codex":[0.9988582,0.0001853164,0.0004380579,0.0002033702,0.0001140856,0.0002010257],"domain_scores_gemma":[0.9988695,0.00003571241,0.0006712904,0.0001868157,0.0001358375,0.000100848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003255342,0.00004168701,0.000384624,0.00001688196,0.00005732017,0.000007004849,0.0001183837,0.00001527333,0.9922655,0.0007248329,0.000003101099,0.006039914],"study_design_scores_gemma":[0.0007807854,0.002360273,0.006001069,0.00003937653,0.00002434441,0.00007069826,0.0001434707,0.00009670443,0.986584,0.003362903,0.0004098283,0.0001265338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9401386,0.0007115139,0.0586607,0.00009541196,0.000140459,0.0001441019,0.00008782645,0.000002695382,0.00001873516],"genre_scores_gemma":[0.9971984,0.000937195,0.001368862,0.00013961,0.00009010768,0.000001999106,0.0002394503,0.00001772407,0.000006640496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05729184,"threshold_uncertainty_score":0.4567609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003987544681063077,"score_gpt":0.2544171721893915,"score_spread":0.2504296275083284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}