{"id":"W2015187915","doi":"10.2165/00063030-200822040-00002","title":"Strategies Toward the Improved Oral Delivery of Insulin Nanoparticles via Gastrointestinal Uptake and Translocation","year":2008,"lang":"en","type":"review","venue":"BioDrugs","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Insulin; Glycemic; Gastrointestinal tract; Nanoparticle; Diabetes mellitus; Nanotechnology; Pharmacology; Medicine; Chemistry; Materials science; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004452577,0.001003589,0.001300347,0.001042753,0.0002040944,0.0008675411,0.0008170962,0.001038902,0.001310156],"category_scores_gemma":[0.0001856616,0.0003477875,0.0004746359,0.0008659583,0.0005061766,0.001107214,0.000645596,0.001565204,0.00135857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006817069,"about_ca_system_score_gemma":0.0004329634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007260182,"about_ca_topic_score_gemma":0.0009816417,"domain_scores_codex":[0.9998909,0.00001555169,0.00000945569,0.00002454824,0.00004201305,0.00001762389],"domain_scores_gemma":[0.9999357,0.00002133624,0.0000149795,0.000003944543,0.0000179771,0.000005965933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001385307,0.0003059311,0.0001263914,0.008024455,0.00006681608,0.0005167621,0.0001142345,0.001315899,0.1295131,0.009964131,0.006193011,0.8437208],"study_design_scores_gemma":[0.0001016861,0.0006903361,0.0008970255,0.0011235,0.0001692161,0.002887851,0.000100146,0.001797474,0.1215316,0.004250431,0.8663791,0.00007160989],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004744276,0.9808414,0.009544963,0.0005456135,0.0002922053,0.00004498123,0.00003682661,0.00006882945,0.003880825],"genre_scores_gemma":[0.01335468,0.9738432,0.006870451,0.0003707887,0.0001425109,0.00006191965,0.0000821662,0.00001246557,0.005261956],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001310156,"threshold_uncertainty_score":0.004946172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1589632605650296,"score_gpt":0.4157631336086455,"score_spread":0.2567998730436158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}