{"id":"W2015218125","doi":"10.1074/jbc.m109.023663","title":"A Conserved Serine Residue Is Required for the Phosphatidate Phosphatase Activity but Not the Transcriptional Coactivator Functions of Lipin-1 and Lipin-2","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; National Human Genome Research Institute; Fondation pour la Recherche Médicale","keywords":"Phosphatidate; Serine; Phosphatase; Residue (chemistry); Coactivator; Chemistry; Biochemistry; Cell biology; Biology; Transcription factor; Phosphorylation; Gene; Protein kinase C","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004717948,0.0001724506,0.0002871661,0.000009942806,0.0001711421,0.00002442117,0.000289112,0.0002013887,0.00005079402],"category_scores_gemma":[0.0003536453,0.00008615911,0.0002385408,0.00006615875,0.000271546,0.00001173447,0.00004167297,0.0001684028,4.277176e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008347446,"about_ca_system_score_gemma":0.0001092934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004811621,"about_ca_topic_score_gemma":8.751102e-7,"domain_scores_codex":[0.9990269,0.00005058304,0.0003797329,0.0002062084,0.0001489192,0.0001876736],"domain_scores_gemma":[0.9989153,0.0001769677,0.0003739474,0.0002508846,0.0001882478,0.00009469518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002111651,0.0001508194,0.0002505342,0.00002511449,0.0001353297,0.000001026693,0.00001927686,0.000001922486,0.99114,0.00001720931,0.001419412,0.004727724],"study_design_scores_gemma":[0.0008269055,0.0002941291,0.01467048,0.00001822117,0.00008447716,0.0000553708,0.00009511657,0.00001222588,0.9414917,0.00003950252,0.04230075,0.0001111249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921561,0.003630598,0.0005517189,0.002991602,0.0001189138,0.000156608,0.00035779,0.000004175282,0.00003243115],"genre_scores_gemma":[0.9968756,0.001077313,0.00031891,0.0007718091,0.0006555056,0.00000883424,0.00002663779,0.000006453514,0.0002588845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04964829,"threshold_uncertainty_score":0.3513466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02821340450169483,"score_gpt":0.2539474788215623,"score_spread":0.2257340743198675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}