{"id":"W2015218125","doi":"10.1074/jbc.m109.023663","title":"A Conserved Serine Residue Is Required for the Phosphatidate Phosphatase Activity but Not the Transcriptional Coactivator Functions of Lipin-1 and Lipin-2","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; National Human Genome Research Institute; Fondation pour la Recherche Médicale","keywords":"Phosphatidate; Serine; Phosphatase; Residue (chemistry); Coactivator; Chemistry; Biochemistry; Cell biology; Biology; Transcription factor; Phosphorylation; Gene; Protein kinase C","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000909576,0.0004550104,0.0002354297,0.0001445661,0.000158958,0.00025291,0.0002046735,0.000266376,0.001322876],"category_scores_gemma":[0.0001793495,0.0001672269,0.0002738595,0.00009265657,0.0003478354,0.0001398496,0.0002037086,0.0002923303,0.0004826504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002978008,"about_ca_system_score_gemma":0.0002532505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004966694,"about_ca_topic_score_gemma":0.0007039701,"domain_scores_codex":[0.9998747,0.00002344993,0.00001988777,0.00003361027,0.0000287482,0.00001961927],"domain_scores_gemma":[0.9997724,0.00005079323,0.00007925535,0.00002230653,0.00001287322,0.00006235323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001316889,0.00001033958,0.0002729458,0.00002505202,0.000004479601,0.0001614899,0.00001037375,0.00003999241,0.9987807,0.00008454661,0.000008604103,0.0004697616],"study_design_scores_gemma":[0.00005547012,0.0002304935,0.01551803,0.000008889263,0.00002614068,0.001430989,0.00003596391,0.001204035,0.9796865,0.00009965244,0.001694625,0.000009219223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974319,0.00037854,0.00153949,0.0000521035,0.0000164682,0.00001218078,0.0001579546,0.0000424143,0.0003688891],"genre_scores_gemma":[0.9977441,0.0001713223,0.001141094,0.00002395508,0.000007629686,0.00001746105,0.0003401421,0.00001455867,0.0005397344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001322876,"threshold_uncertainty_score":0.004425406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02821340450169483,"score_gpt":0.2539474788215623,"score_spread":0.2257340743198675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}