{"id":"W2015247168","doi":"10.1161/circulationaha.107.728865","title":"Deletion of <i>Ptpn11</i> (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Charles A. King Trust; American Heart Association","keywords":"RHOA; MAPK/ERK pathway; Signal transduction; Protein tyrosine phosphatase; Medicine; Cell biology; Pressure overload; Kinase; Protein kinase A; Cancer research; Biology; Internal medicine; Muscle hypertrophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699644,0.0005679785,0.0001760904,0.0002111863,0.0001661184,0.0002307457,0.0002352522,0.0003218312,0.001940442],"category_scores_gemma":[0.0001156421,0.0002031992,0.0002295172,0.0001062361,0.0003336231,0.000174188,0.0002811446,0.0006176961,0.0006843259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002478347,"about_ca_system_score_gemma":0.000165825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003397295,"about_ca_topic_score_gemma":0.0006031762,"domain_scores_codex":[0.9998357,0.00002424127,0.00002228668,0.00004095931,0.00004461182,0.00003220601],"domain_scores_gemma":[0.9997838,0.00002830036,0.00008751534,0.00001428615,0.000009081225,0.00007708264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007666156,0.00001960232,0.0002764019,0.00001993547,0.000005211634,0.0001379341,0.000005613214,0.00004632059,0.9989634,0.00004911115,0.00003990717,0.0003599033],"study_design_scores_gemma":[0.00007473105,0.0004555548,0.01352136,0.00001388127,0.00003339742,0.00233669,0.0000357798,0.001105466,0.9799522,0.00006571461,0.002396364,0.000008852938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943242,0.0004831516,0.003156585,0.0001136333,0.00004263999,0.00003066783,0.0005506125,0.0001032209,0.001195333],"genre_scores_gemma":[0.993339,0.0005735224,0.00276328,0.00008781095,0.00002685912,0.00006749645,0.0009014619,0.00006015959,0.00218037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001940442,"threshold_uncertainty_score":0.006491363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293091010385856,"score_gpt":0.201956974517542,"score_spread":0.1890260644136834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}