{"id":"W2015247168","doi":"10.1161/circulationaha.107.728865","title":"Deletion of <i>Ptpn11</i> (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Charles A. King Trust; American Heart Association","keywords":"RHOA; MAPK/ERK pathway; Signal transduction; Protein tyrosine phosphatase; Medicine; Cell biology; Pressure overload; Kinase; Protein kinase A; Cancer research; Biology; Internal medicine; Muscle hypertrophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003549325,0.0002989403,0.0003238638,0.0001232139,0.0001771336,0.00002099937,0.0001384592,0.0002370754,0.000006201773],"category_scores_gemma":[0.0002046967,0.0002652591,0.0001204613,0.0003747417,0.0001462884,0.00002098252,0.0000675054,0.0001551081,0.000002775372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005386398,"about_ca_system_score_gemma":0.00007435283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000146601,"about_ca_topic_score_gemma":0.000005434598,"domain_scores_codex":[0.9981561,0.0003540436,0.0004011853,0.0005060743,0.0002862939,0.0002963134],"domain_scores_gemma":[0.9989913,0.0000772035,0.0002412083,0.0004499736,0.0001665278,0.00007380322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002217755,0.00005651757,0.006760988,0.00009271862,0.00007119496,0.00004307268,0.0001061145,0.003437589,0.9871264,0.0001723525,0.0000176528,0.001893603],"study_design_scores_gemma":[0.0009088264,0.0001970112,0.02301873,0.0001733731,0.00003803105,0.00002511042,0.00001839464,0.0008004226,0.9742267,0.0001896057,0.0001179272,0.0002859259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870104,0.009022208,0.002429603,0.00003668185,0.0000704782,0.00134728,0.00003042318,0.00003797879,0.00001494872],"genre_scores_gemma":[0.9991081,0.0000600792,0.00009936688,0.00003614561,0.0001032714,0.0001644721,0.0003759367,0.00004610281,0.000006461552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01625774,"threshold_uncertainty_score":0.99998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293091010385856,"score_gpt":0.201956974517542,"score_spread":0.1890260644136834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}