{"id":"W2015277191","doi":"10.1021/ja027976r","title":"Reactivity of Intermediates in Benzoylformate Decarboxylase:  Avoiding the Path to Destruction","year":2002,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Carbanion; Decarboxylation; Benzaldehyde; Reactivity (psychology); Enamine; Protonation; Cofactor; Enzyme; Enzyme catalysis; Stereochemistry; Organic chemistry; Medicinal chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004149301,0.00009696914,0.0002063924,0.00001264941,0.00005490973,0.000009209537,0.0004025495,0.00004810702,0.000002987816],"category_scores_gemma":[0.0007215735,0.00005225768,0.0002790829,0.0002694911,0.0004374189,0.000006145492,0.0003196356,0.0003999293,5.882745e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006337056,"about_ca_system_score_gemma":0.00001915905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002134863,"about_ca_topic_score_gemma":0.000001854814,"domain_scores_codex":[0.9990746,0.00008502961,0.0002838094,0.0001079764,0.0002468402,0.0002016999],"domain_scores_gemma":[0.9992279,0.00008878439,0.0003410428,0.0001756379,0.000103843,0.00006272677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006392458,0.00005499835,0.006508291,0.00001194378,0.00005248344,3.921353e-7,0.0002612101,0.000008122687,0.9876071,9.147159e-7,0.003313719,0.002116926],"study_design_scores_gemma":[0.0001881385,0.0001471944,0.005369253,0.0000359873,0.0000121516,0.00002737624,0.0005268617,0.00007744652,0.9929628,0.00004737107,0.0005404375,0.00006500551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976057,0.000264405,0.00005818389,0.001901892,0.00005399205,0.00006937226,0.000004891065,0.000001610375,0.00003999801],"genre_scores_gemma":[0.9982915,0.0005748165,0.0006484364,0.0002974748,0.0001667298,0.000003485634,5.277159e-7,0.000007503237,0.000009522467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005355702,"threshold_uncertainty_score":0.2131007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059592865253353,"score_gpt":0.259953211147058,"score_spread":0.2493572824945245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}