{"id":"W2015308063","doi":"10.1021/bi061489x","title":"The Hydrolase and Transferase Activity of an Inverting Mutant Sialidase Using Non-natural β-Sialoside Substrates","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Simon Fraser University","keywords":"Sialidase; Enzyme kinetics; Chemistry; Sialic acid; Mutant; Hydrolysis; Hydrolase; Residue (chemistry); Stereochemistry; Transferase; Biochemistry; Tyrosine; Enzyme; Lactose; Neuraminic acid; Active site; Neuraminidase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011361,0.0004060351,0.0002519836,0.0001626635,0.00006400089,0.0002521439,0.0002161185,0.0002291256,0.0004358719],"category_scores_gemma":[0.0002144992,0.000119331,0.0003125955,0.0002388189,0.0001589215,0.000171736,0.0001905408,0.0002419503,0.0001680896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002728907,"about_ca_system_score_gemma":0.00023523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002006835,"about_ca_topic_score_gemma":0.001442704,"domain_scores_codex":[0.9998493,0.00002277958,0.0000192546,0.00004411249,0.00004040422,0.00002409914],"domain_scores_gemma":[0.9999121,0.00001218166,0.00002240186,0.00001459418,0.00001367061,0.00002489941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005043144,0.000008298638,0.0006926433,0.000009323605,0.000008004597,0.00001983399,0.000007546786,0.00006939557,0.9979841,0.00002209449,0.000006452929,0.001121872],"study_design_scores_gemma":[0.000005184584,0.0002212505,0.01082672,0.000002526803,0.00002756432,0.0003760266,0.0000261138,0.001423202,0.9865038,0.00002427109,0.0005579806,0.000005475673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979548,0.0003363428,0.001179678,0.0000147088,0.000003860305,0.000009681381,0.0002070182,0.00002053708,0.000273411],"genre_scores_gemma":[0.9958256,0.0002859861,0.00221771,0.000007900141,0.000001490182,0.00001138461,0.0007277434,0.0000136381,0.0009084981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006835,"threshold_uncertainty_score":0.003990293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008787931557939532,"score_gpt":0.2624140337503816,"score_spread":0.253626102192442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}