{"id":"W2015360869","doi":"10.1016/j.redox.2015.03.003","title":"Expression of xCT and activity of system xc− are regulated by NRF2 in human breast cancer cells in response to oxidative stress","year":2015,"lang":"en","type":"article","venue":"Redox Biology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":270,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Oxidative stress; Human breast; Breast cancer; Cell biology; Cancer; Cancer cell; Oxidative phosphorylation; Cancer research; Expression (computer science); Biology; Chemistry; Biochemistry; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002782841,0.0001506811,0.0003634107,0.00009437784,0.00001393316,0.000002779248,0.0001550667,0.0002450767,0.000002531472],"category_scores_gemma":[0.00005305282,0.000138311,0.00003135717,0.0001073279,0.0001579972,0.000004111489,0.0001692875,0.00008574146,3.154616e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005580065,"about_ca_system_score_gemma":0.00005850017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005613327,"about_ca_topic_score_gemma":0.0002649878,"domain_scores_codex":[0.9987096,0.0003689156,0.0002812821,0.0003805955,0.00005551126,0.0002041089],"domain_scores_gemma":[0.9992764,0.00003094312,0.0002262327,0.0002573773,0.0001166931,0.00009234874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001987621,0.0001016643,0.03186989,0.0000713907,0.00001481653,0.00000140782,0.0002065946,0.00005621189,0.9653022,0.000004436064,0.0001981663,0.0001855935],"study_design_scores_gemma":[0.0009315903,0.0002429661,0.03659935,0.0002151622,0.00000449067,0.000002186921,0.0004989101,0.00001020723,0.9612423,0.0000169521,0.0001044875,0.0001314574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981185,0.0004834353,0.00004959823,0.00006777229,0.00004804032,0.0002430263,0.000946939,0.000003743127,0.00003894988],"genre_scores_gemma":[0.9996913,0.00004935818,0.00007755198,0.00001236043,0.00002857102,0.00002483842,0.00007196219,0.00001052239,0.00003350036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00472946,"threshold_uncertainty_score":0.5640159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038444253426469,"score_gpt":0.2695078243418154,"score_spread":0.2591233818075507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}