{"id":"W2015365345","doi":"10.1007/s11307-006-0057-0","title":"99mTc-Sestamibi, A Sensitive Probe for In Vivo Imaging of P-Glycoprotein Inhibition by Modulators and mdr1 Antisense Oligodeoxynucleotides","year":2006,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"","keywords":"P-glycoprotein; In vivo; Biodistribution; Molecular biology; Daunorubicin; In vitro; Chemistry; Pharmacology; Biology; Medicine; Multiple drug resistance; Chemotherapy; Biochemistry; Internal medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004814714,0.0005377111,0.0005282976,0.000642703,0.0003600226,0.0007334142,0.0005928216,0.0009261108,0.001054132],"category_scores_gemma":[0.000372897,0.0005680318,0.0001928997,0.0004221023,0.0004851773,0.0005668903,0.0003966544,0.001163405,0.0003517074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007152692,"about_ca_system_score_gemma":0.0005099426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317655,"about_ca_topic_score_gemma":0.001819759,"domain_scores_codex":[0.9997814,0.00007043543,0.000009052462,0.00004431517,0.00004668297,0.00004808829],"domain_scores_gemma":[0.9998599,0.00005371324,0.00002670141,0.00001409283,0.00001475021,0.00003073789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002696096,0.00001529189,0.00008482882,0.00004485525,0.000008229622,0.00008676804,0.00001982319,0.00008680587,0.9958791,0.0005902472,0.0001202761,0.002794161],"study_design_scores_gemma":[0.00005187905,0.0002414385,0.0007209452,0.000009102855,0.00003523557,0.0008623648,0.00001715457,0.002119549,0.9914384,0.0001640936,0.004328843,0.00001090243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8736046,0.0188977,0.09072512,0.001304089,0.0001782559,0.0002193472,0.0003662852,0.0006717761,0.01403289],"genre_scores_gemma":[0.9415525,0.004062776,0.04707852,0.0003820123,0.00005590325,0.000152656,0.0004383114,0.000150022,0.006127405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001317655,"threshold_uncertainty_score":0.005189657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004323707035082613,"score_gpt":0.2268293911672475,"score_spread":0.2225056841321649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}