{"id":"W2015365345","doi":"10.1007/s11307-006-0057-0","title":"99mTc-Sestamibi, A Sensitive Probe for In Vivo Imaging of P-Glycoprotein Inhibition by Modulators and mdr1 Antisense Oligodeoxynucleotides","year":2006,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"","keywords":"P-glycoprotein; In vivo; Biodistribution; Molecular biology; Daunorubicin; In vitro; Chemistry; Pharmacology; Biology; Medicine; Multiple drug resistance; Chemotherapy; Biochemistry; Internal medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655573,0.0001530906,0.0003110247,0.0001408497,0.00004187744,0.000009448149,0.00001680376,0.00005653478,0.000001632911],"category_scores_gemma":[0.00001493646,0.0001324182,0.00005093931,0.00009914883,0.0002121969,0.0000386517,0.00001517311,0.00008147154,1.437822e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001612168,"about_ca_system_score_gemma":0.00002018534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003505253,"about_ca_topic_score_gemma":0.00002751549,"domain_scores_codex":[0.9990938,0.00003482218,0.0002482603,0.0003231731,0.00005277838,0.0002471691],"domain_scores_gemma":[0.9996992,0.00001980405,0.00007596971,0.00009714906,0.00006285119,0.0000450091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121171,0.00006174745,0.0317461,0.0001330389,0.00001142992,0.000110224,0.0000624553,0.000001849198,0.9648164,0.0009919332,0.00006293487,0.001889772],"study_design_scores_gemma":[0.002198765,0.00009901341,0.00768831,0.0002776878,0.00005970223,0.0001354246,0.0001827787,0.001681226,0.9836475,0.003472935,0.0003681243,0.0001884985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723292,0.001472661,0.02456068,0.00089878,0.00003339071,0.0004989323,0.00005518557,0.00002943994,0.0001217325],"genre_scores_gemma":[0.9958338,0.00005260223,0.003688541,0.0002593106,0.00002132087,0.00001729076,0.00006733278,0.00002081563,0.00003897113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02405779,"threshold_uncertainty_score":0.5399856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004323707035082613,"score_gpt":0.2268293911672475,"score_spread":0.2225056841321649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}