{"id":"W2015365870","doi":"10.1016/j.cct.2014.06.004","title":"Rationale and design of a multicenter randomized clinical trial with memantine and dextromethorphan in ketamine-responder patients","year":2014,"lang":"en","type":"article","venue":"Contemporary Clinical Trials","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Dextromethorphan; Memantine; Medicine; Ketamine; Neuropathic pain; Anesthesia; Placebo; Adverse effect; Randomized controlled trial; Clinical trial; NMDA receptor; Montreal Cognitive Assessment; Pharmacology; Internal medicine; Cognition; Psychiatry; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.05312684,0.00023081,0.00327551,0.0001559274,0.00002988986,0.00001822045,0.00006348939,0.000242954,0.00004167481],"category_scores_gemma":[0.05827287,0.0001386602,0.0003150437,0.0001113886,0.0003600577,0.0001086243,0.00005023139,0.0002247402,0.000003094019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007587671,"about_ca_system_score_gemma":0.0001547977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001461509,"about_ca_topic_score_gemma":0.000002118699,"domain_scores_codex":[0.9808188,0.01469661,0.003486886,0.0005197033,0.0003071098,0.0001708998],"domain_scores_gemma":[0.9486297,0.049342,0.001224043,0.0003275082,0.0001859081,0.0002908497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8681538,0.001914988,0.1187356,0.00004434341,0.0005102489,0.00001719117,0.00003562331,3.900604e-7,0.00007364443,0.0001376508,0.0001599454,0.01021655],"study_design_scores_gemma":[0.957967,0.005565043,0.03280398,0.0002415983,0.000428363,0.000001800775,0.00001435104,0.00181404,0.00009615269,0.000596743,0.0003332292,0.0001376438],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713735,0.0004998163,0.01851738,0.0005740478,0.0003408825,0.008502739,0.00001515183,0.00001970047,0.000156797],"genre_scores_gemma":[0.9837967,0.0002843125,0.01467046,0.0005020623,0.0002424651,0.0001621816,0.00004193332,0.00002315464,0.0002767067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08981326,"threshold_uncertainty_score":0.9750051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3213737142798989,"score_gpt":0.4738635955982698,"score_spread":0.1524898813183709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}