{"id":"W2015377426","doi":"10.1002/prp2.65","title":"Intranasal<scp>NAP</scp>(davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α‐synuclein","year":2014,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paladin Labs (Canada)","funders":"National Institutes of Health; Yükseköğretim Kurulu; Michael J. Fox Foundation for Parkinson's Research","keywords":"Nap; Hyperphosphorylation; Cerebellum; Habituation; Striatum; Parkinson's disease; Internal medicine; Endocrinology; Medicine; Neuroscience; Biology; Chemistry; Phosphorylation; Disease; Biochemistry; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225979,0.0008131895,0.000555052,0.0004955133,0.0001750747,0.0003303483,0.0003485233,0.0006595986,0.001033041],"category_scores_gemma":[0.0001501502,0.0002444821,0.000299911,0.0001691978,0.0003773426,0.0003304226,0.0001670649,0.001091107,0.0003162484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002213073,"about_ca_system_score_gemma":0.0002301823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171979,"about_ca_topic_score_gemma":0.002454013,"domain_scores_codex":[0.9998614,0.00001848972,0.00001481223,0.00004025801,0.00002854592,0.00003655205],"domain_scores_gemma":[0.9997135,0.00002997427,0.0001053514,0.00001715077,0.00001958202,0.0001144223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001275956,0.0002971586,0.0001734642,0.00005927153,0.00001742673,0.00006667917,0.00001601268,0.00006934417,0.9954366,0.00002697401,0.00009253938,0.002468487],"study_design_scores_gemma":[0.0004859315,0.01596656,0.01691216,0.00004219883,0.00009873247,0.0006991549,0.0001074579,0.001180792,0.9610491,0.0001079193,0.003318138,0.00003198333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968209,0.001137121,0.0004613243,0.0001120373,0.00003896242,0.0000266313,0.0005275257,0.0002410272,0.000634274],"genre_scores_gemma":[0.991609,0.001913418,0.001804977,0.0001393573,0.00003429759,0.00008723986,0.001255527,0.00006787317,0.003088203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171979,"threshold_uncertainty_score":0.003455877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04998444665227508,"score_gpt":0.3868821000847844,"score_spread":0.3368976534325093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}