{"id":"W2015451666","doi":"10.1021/jm049221w","title":"3-Substituted Imidazo[1,2-<i>d</i>][1,2,4]-thiadiazoles:  A Novel Class of Factor XIIIa Inhibitors","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Apotex (Canada)","funders":"","keywords":"Factor XIIIa; Chemistry; Thiadiazoles; Pharmacophore; Fibrinolysis; Bicyclic molecule; Fibrin; Activator (genetics); Stereochemistry; Plasminogen activator; Biochemistry; Medicinal chemistry; Internal medicine; Immunology; Fibrinogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006192323,0.0002178464,0.0003089404,0.0001230411,0.0001353262,0.0001773559,0.0003124647,0.0002122135,0.001683662],"category_scores_gemma":[0.00009717793,0.00009801655,0.0000789155,0.0001549293,0.0001573255,0.0001459886,0.0001005314,0.0004250179,0.000606946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003597282,"about_ca_system_score_gemma":0.0002100531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009642889,"about_ca_topic_score_gemma":0.00231904,"domain_scores_codex":[0.9999597,0.000006028566,0.000002176452,0.000007526759,0.000009335249,0.00001531383],"domain_scores_gemma":[0.9999706,0.000003464026,0.000007743042,0.000002347958,0.000004838168,0.00001097865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001106125,0.0001053617,0.0003567575,0.000266441,0.0000143968,0.0004038853,0.0000805925,0.0008903064,0.9642331,0.001349175,0.001737341,0.02945655],"study_design_scores_gemma":[0.001046291,0.004261587,0.008172962,0.00005135726,0.00009042522,0.004527716,0.00007206206,0.004974988,0.8984792,0.0006419435,0.07761969,0.00006179003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9348688,0.03607428,0.01272565,0.0008857292,0.0002964689,0.00008932718,0.0009641629,0.0007327304,0.01336297],"genre_scores_gemma":[0.9754418,0.01109061,0.005223735,0.0001965615,0.00006508999,0.00005567086,0.0005809513,0.00002232028,0.007323285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001683662,"threshold_uncertainty_score":0.005632401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824555864147935,"score_gpt":0.253311129174252,"score_spread":0.2350655705327726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}