{"id":"W2015451666","doi":"10.1021/jm049221w","title":"3-Substituted Imidazo[1,2-<i>d</i>][1,2,4]-thiadiazoles:  A Novel Class of Factor XIIIa Inhibitors","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Apotex (Canada)","funders":"","keywords":"Factor XIIIa; Chemistry; Thiadiazoles; Pharmacophore; Fibrinolysis; Bicyclic molecule; Fibrin; Activator (genetics); Stereochemistry; Plasminogen activator; Biochemistry; Medicinal chemistry; Internal medicine; Immunology; Fibrinogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002943642,0.0001871475,0.0005614302,0.00008113128,0.0000386577,0.000008646752,0.0001542476,0.0001993587,0.0003857658],"category_scores_gemma":[0.0002434164,0.0001359271,0.0002359982,0.0001869748,0.0001474368,0.0001483404,0.00002803178,0.0005817576,0.000004791591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001301532,"about_ca_system_score_gemma":0.0004218173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001431945,"about_ca_topic_score_gemma":0.00000166731,"domain_scores_codex":[0.9979004,0.00001177831,0.0009292133,0.0001390846,0.0007937943,0.0002257155],"domain_scores_gemma":[0.9982713,0.00005264522,0.0006712953,0.0002094368,0.0004841774,0.0003110822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008150213,0.0004336638,0.006893707,0.000474665,0.0002373002,0.00005018318,0.0006007464,0.0001794518,0.9774591,0.000009504896,0.002002835,0.01084377],"study_design_scores_gemma":[0.00653199,0.0003904065,0.01419062,0.001741471,0.0005717255,0.002419013,0.0008828902,0.0009493281,0.9523462,0.00001539065,0.01973611,0.000224844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922569,0.002346722,0.0001696696,0.003342073,0.0002268193,0.00008849853,0.000006736885,0.0000146414,0.001547965],"genre_scores_gemma":[0.9962698,0.000133948,0.0008407352,0.0003817689,0.002170099,0.000001305034,0.000005940129,0.00002041082,0.0001760556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02511294,"threshold_uncertainty_score":0.5542946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824555864147935,"score_gpt":0.253311129174252,"score_spread":0.2350655705327726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}