{"id":"W2015495442","doi":"10.1038/srep06315","title":"Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; London Health Sciences Centre; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Breast Cancer Society of Canada","keywords":"RHOA; Cancer research; Wnt signaling pathway; Gene knockdown; Biology; Cell polarity; Cell biology; Cancer cell; Frizzled; WNT5A; Cell; Cancer; Cell culture; Chemistry; Signal transduction; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168163,0.0001744628,0.0002314581,0.0002743542,0.0001191693,0.0004830131,0.00007440658,0.0001757404,0.001618162],"category_scores_gemma":[0.0001740614,0.0001717724,0.0001783339,0.0002275722,0.0001365476,0.0001690156,0.0001360645,0.0003925455,0.0003769353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000322447,"about_ca_system_score_gemma":0.0003059478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218156,"about_ca_topic_score_gemma":0.001869236,"domain_scores_codex":[0.9998461,0.00002739701,0.00001269315,0.00002660407,0.00004136777,0.00004593367],"domain_scores_gemma":[0.9999,0.00001774763,0.00002581263,0.000006800446,0.00002104225,0.00002854006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002763469,0.00002127795,0.001949177,0.00004169509,0.00000503695,0.00005279245,0.00002688169,0.00003260971,0.9960841,0.00004482874,0.00005930573,0.001406073],"study_design_scores_gemma":[0.00002614827,0.0003757061,0.1073632,0.0000107666,0.00003920135,0.0004752649,0.0001788352,0.0008418589,0.8862769,0.00006484721,0.004333934,0.00001351951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953567,0.001906154,0.000567242,0.00006360927,0.00001473761,0.00002175883,0.0004012251,0.0000317208,0.001636826],"genre_scores_gemma":[0.9958172,0.00146614,0.000407458,0.00003382747,0.000006103989,0.00002559312,0.000538529,0.00001166867,0.001693486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618162,"threshold_uncertainty_score":0.005413353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008181824337086786,"score_gpt":0.2482840022104323,"score_spread":0.2401021778733455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}