{"id":"W2015514143","doi":"10.1016/s1043-2760(02)00011-5","title":"Secretory granule biogenesis and chromogranin A: master gene, on/off switch or assembly factor?","year":2003,"lang":"en","type":"review","venue":"Trends in Endocrinology and Metabolism","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Chromogranin A; Granule (geology); Biogenesis; Secretory protein; Cell biology; Biology; Secretory pathway; Secretory Vesicle; Secretion; Gene; Enteroendocrine cell; Gene expression; Exocytosis; Endocrine system; Endocrinology; Immunology; Genetics; Golgi apparatus; Endoplasmic reticulum; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006481489,0.001234563,0.002121438,0.001110702,0.0003242766,0.001459755,0.001667196,0.001717655,0.002940863],"category_scores_gemma":[0.0005419744,0.0003146275,0.0003685104,0.00182244,0.0007422232,0.002000572,0.0006116658,0.002008565,0.004104146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001001906,"about_ca_system_score_gemma":0.001025351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009808869,"about_ca_topic_score_gemma":0.001300812,"domain_scores_codex":[0.999848,0.00001738919,0.00002248468,0.00003921028,0.0000535472,0.00001932979],"domain_scores_gemma":[0.9997882,0.0000593523,0.00003226209,0.000008253184,0.0000678505,0.00004403342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002988213,0.00007385801,0.0002924168,0.007299493,0.00008567949,0.0006960622,0.00006143651,0.0003921725,0.01229802,0.005574521,0.07211068,0.9008168],"study_design_scores_gemma":[0.00003828901,0.00006743138,0.0007241669,0.0006179083,0.00008093726,0.00134151,0.00007557944,0.00009407153,0.001781472,0.001925136,0.9932345,0.0000190886],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003379495,0.9960352,0.0004909923,0.0006396852,0.000958099,0.000006096481,0.00003559515,0.00003031247,0.001466189],"genre_scores_gemma":[0.001415224,0.9946581,0.0005511743,0.0004802034,0.0006355282,0.00001029036,0.00009743316,0.000004144918,0.002147857],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002940863,"threshold_uncertainty_score":0.009838164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04751193394786669,"score_gpt":0.3014605426043241,"score_spread":0.2539486086564575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}