{"id":"W2015514843","doi":"10.1074/jbc.m110.197921","title":"Essential Role for Mnk Kinases in Type II Interferon (IFNγ) Signaling and Its Suppressive Effects on Normal Hematopoiesis","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"EIF4E; Haematopoiesis; Biology; Kinase; Gene knockdown; MAPK/ERK pathway; Cell biology; Signal transduction; Interferon; Translation (biology); PI3K/AKT/mTOR pathway; Cancer research; Immunology; Messenger RNA; Stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001517145,0.0001188744,0.0003050202,0.00004301023,0.00005760992,0.00001494262,0.00007374598,0.0001661528,0.0002673155],"category_scores_gemma":[0.0008679152,0.00007880991,0.000118835,0.00005587399,0.00004224271,0.00004842434,0.00004184017,0.0005081603,0.000001284079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002096008,"about_ca_system_score_gemma":0.0000378966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001199128,"about_ca_topic_score_gemma":4.054023e-7,"domain_scores_codex":[0.9992998,0.00001375572,0.0003043921,0.0001331765,0.00009537545,0.0001534818],"domain_scores_gemma":[0.9991577,0.0003228856,0.0001828026,0.00006670635,0.0001588148,0.0001110803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001132759,0.0002040843,0.0007104314,0.0001098938,0.00003364816,0.0000519101,0.00005544641,0.000005209057,0.9970897,0.000012985,0.0001638049,0.0004301036],"study_design_scores_gemma":[0.001129096,0.001727186,0.0007547783,0.0003487133,0.00004003831,0.0003726655,0.00008499919,0.00009380967,0.9946721,0.00007814152,0.0006145018,0.00008399884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988734,0.0002508583,0.0000188616,0.0002929715,0.0002101579,0.0000981869,0.000007654833,0.000008128216,0.0002398082],"genre_scores_gemma":[0.998901,0.00002572168,0.0001995774,0.00009624079,0.0007098282,0.000005139834,0.000009081968,0.000007517277,0.00004590481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002417653,"threshold_uncertainty_score":0.3213775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164781173039305,"score_gpt":0.2833711382486209,"score_spread":0.2668930209446904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}