{"id":"W2015543883","doi":"10.1074/jbc.m006001200","title":"Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Glucokinase; Internal medicine; Endocrinology; Peroxisome; Peroxisome proliferator-activated receptor; Carbohydrate metabolism; Lipid metabolism; Beta oxidation; Glucose uptake; Biology; Carnitine; Receptor; Chemistry; Insulin; Biochemistry; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006431506,0.000414486,0.0002225763,0.0002085501,0.00008921159,0.0003949762,0.0001226772,0.00018663,0.001290253],"category_scores_gemma":[0.00007508363,0.0001572841,0.0002427614,0.0002058399,0.0001434128,0.0001813866,0.0001647584,0.0005080219,0.0005130926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002547787,"about_ca_system_score_gemma":0.0001453484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007108577,"about_ca_topic_score_gemma":0.0005112864,"domain_scores_codex":[0.9999086,0.00001267512,0.00001069941,0.00002278467,0.0000217411,0.00002349083],"domain_scores_gemma":[0.9999251,0.000009721008,0.00001999358,0.00001038635,0.00001384068,0.00002094542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002451965,0.00003313609,0.0003777092,0.00004208281,0.000007800545,0.0000572697,0.000008941629,0.00002169217,0.9970132,0.00004377799,0.00004107939,0.002108011],"study_design_scores_gemma":[0.00007984989,0.001075301,0.06812032,0.00004479356,0.00007220876,0.0004854815,0.0001318768,0.000685602,0.9211912,0.000244886,0.007858094,0.00001039515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821848,0.01153308,0.002503906,0.0002170102,0.0002005268,0.00002087426,0.0004608258,0.0001309436,0.002748013],"genre_scores_gemma":[0.9800057,0.01183079,0.001816068,0.0002872973,0.00008756408,0.0000533262,0.001008525,0.00004749815,0.004863134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290253,"threshold_uncertainty_score":0.00431633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01604580276458696,"score_gpt":0.2327539151655508,"score_spread":0.2167081124009638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}