{"id":"W2015639284","doi":"10.1210/en.2014-1329","title":"DYRK1A BAC Transgenic Mouse: A New Model of Thyroid Dysgenesis in Down Syndrome","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Thyroid; Internal medicine; Endocrinology; Thyroglobulin; Genetically modified mouse; PAX8; Congenital hypothyroidism; Biology; Transgene; Medicine; Transcription factor; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004236527,0.001203769,0.0006756458,0.002246204,0.0006208718,0.0006198916,0.0008494254,0.001376617,0.005661774],"category_scores_gemma":[0.0002093127,0.0006481119,0.0005417244,0.0006604418,0.0006551257,0.0006069569,0.0005827608,0.001480668,0.001665578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004629532,"about_ca_system_score_gemma":0.0003450515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009775232,"about_ca_topic_score_gemma":0.001977751,"domain_scores_codex":[0.9993761,0.00007180026,0.0001085686,0.0002218067,0.0001414541,0.00008030487],"domain_scores_gemma":[0.9996693,0.00005131805,0.00009093363,0.00003732539,0.00003691235,0.0001141482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001767561,0.0001128738,0.000417323,0.00006762937,0.00001467623,0.0005934513,0.00005934558,0.00007217849,0.9961935,0.0006294419,0.000224592,0.001438242],"study_design_scores_gemma":[0.0004369458,0.001896316,0.01649993,0.0001173926,0.0003057246,0.01492946,0.0002807537,0.003969233,0.9224839,0.000774591,0.03821586,0.00008995156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959852,0.002899834,0.02323137,0.0006020895,0.0003398653,0.0002966442,0.006991087,0.0009246073,0.004862569],"genre_scores_gemma":[0.9124284,0.005203103,0.03340352,0.0003911215,0.0001242974,0.0009296726,0.009114051,0.0006344743,0.03777133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005661774,"threshold_uncertainty_score":0.01894057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0425608385655193,"score_gpt":0.3055055038458368,"score_spread":0.2629446652803175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}