{"id":"W2015645387","doi":"10.1038/mt.2010.26","title":"Transcriptional and Translational Dual-regulated Oncolytic Herpes Simplex Virus Type 1 for Targeting Prostate Tumors","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Terry Fox Foundation","keywords":"Oncolytic virus; Herpes simplex virus; Virology; Cancer research; Biology; Virus; Dual (grammatical number)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003906577,0.000359423,0.0002611019,0.0003196043,0.0002427713,0.0006798198,0.0003465028,0.0003167529,0.001292624],"category_scores_gemma":[0.0002077678,0.0002011911,0.0003344631,0.0002210747,0.0004572002,0.000387812,0.0003368216,0.001261986,0.0003278999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009602888,"about_ca_system_score_gemma":0.000572713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007159826,"about_ca_topic_score_gemma":0.001245152,"domain_scores_codex":[0.9997358,0.00003547168,0.00001612253,0.00005554314,0.00008835114,0.00006875441],"domain_scores_gemma":[0.9999188,0.00001198799,0.00002044308,0.00001411232,0.00001260798,0.00002190378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002771813,0.00009152917,0.0001303664,0.00004618107,0.000006635146,0.00002582127,0.0000291406,0.0002848811,0.9910852,0.002259665,0.0001974191,0.005565977],"study_design_scores_gemma":[0.00002518458,0.0002128142,0.0005149753,0.000003917116,0.00002081553,0.0001190998,0.00001752679,0.00153339,0.9933584,0.0001570204,0.004029744,0.00000703141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961304,0.007685665,0.02324524,0.0005337237,0.0003566165,0.0001466227,0.0007145627,0.0003194579,0.005694024],"genre_scores_gemma":[0.9833215,0.001222981,0.007712288,0.00008104464,0.0000439594,0.00005669705,0.0005030801,0.00004816499,0.007010271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292624,"threshold_uncertainty_score":0.006967425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586924130199208,"score_gpt":0.2970149210796898,"score_spread":0.2811456797776977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}