{"id":"W2015657386","doi":"10.1016/j.cbi.2009.07.001","title":"Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells","year":2009,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Antioxidant Activity and Oxidative Stress","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Acrolein; Reactive oxygen species; Apoptosis; Chemistry; Oxidative stress; Mitochondrion; Cytochrome c; Programmed cell death; Cell biology; Caspase; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002157936,0.0003371638,0.0002724597,0.0003394956,0.0002654471,0.0002644465,0.0001553251,0.0003914071,0.002166346],"category_scores_gemma":[0.0001462195,0.0001683295,0.0003770561,0.0002764672,0.0001959682,0.0002739569,0.0002113529,0.0006095861,0.0004101798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000275849,"about_ca_system_score_gemma":0.0001619511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008111135,"about_ca_topic_score_gemma":0.0008636844,"domain_scores_codex":[0.9996865,0.00007128564,0.00003652572,0.00003846144,0.00008566539,0.00008165133],"domain_scores_gemma":[0.9998504,0.00004623231,0.00002434874,0.00002530115,0.00002530765,0.00002850671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005749529,0.00008766946,0.0004282406,0.00003779293,0.00001281027,0.0001954991,0.00002818626,0.00004194745,0.9976798,0.00006722056,0.00006502639,0.0007809394],"study_design_scores_gemma":[0.00004116577,0.0009120243,0.009001092,0.000004819713,0.00002052869,0.0003666281,0.00009652249,0.000436739,0.987559,0.00005985701,0.001496321,0.000005217056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951109,0.001322599,0.001253928,0.0001892692,0.00007913871,0.0000343143,0.0003457192,0.00005256843,0.001611515],"genre_scores_gemma":[0.9965031,0.0005771476,0.0004771851,0.0000642724,0.00002134074,0.0000241822,0.0004614282,0.000005172222,0.00186608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002166346,"threshold_uncertainty_score":0.00724721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03345427976013806,"score_gpt":0.306624981124333,"score_spread":0.273170701364195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}