{"id":"W2015674852","doi":"10.1016/j.tig.2006.05.008","title":"To be or not to be toxic: aggregations in Huntington and Alzheimer disease","year":2006,"lang":"en","type":"article","venue":"Trends in Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"","keywords":"Disease; Huntington's disease; Biology; Protein aggregation; Alzheimer's disease; Neurodegeneration; Pathology; Neuroscience; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007743631,0.0003828495,0.000394271,0.0005828261,0.000821663,0.0009802156,0.000221416,0.001137303,0.001637934],"category_scores_gemma":[0.001974303,0.0001646969,0.0001784269,0.0007113222,0.0006611818,0.001050504,0.0003831652,0.001037592,0.0002623608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004957188,"about_ca_system_score_gemma":0.0002214145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001734662,"about_ca_topic_score_gemma":0.004499104,"domain_scores_codex":[0.9997966,0.00007633401,0.0000233555,0.00002495156,0.00005421681,0.00002459672],"domain_scores_gemma":[0.9993945,0.0001872871,0.0001856422,0.00003899958,0.00007864336,0.00011487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.01376457,0.001031159,0.250063,0.001297898,0.0008003163,0.01750724,0.005909202,0.006081372,0.1114006,0.05922594,0.09011889,0.4427999],"study_design_scores_gemma":[0.0002363767,0.001572977,0.5635,0.0005089063,0.001016851,0.04494254,0.005568356,0.008925785,0.01734638,0.3077038,0.04845702,0.0002209822],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9365883,0.04001801,0.001635698,0.01241661,0.0004361573,0.00001455221,0.0002703504,0.0000420603,0.008578186],"genre_scores_gemma":[0.9847787,0.009595871,0.001144081,0.0009358014,0.000360549,0.000008266597,0.0001589548,0.00001913097,0.002998623],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001734662,"threshold_uncertainty_score":0.005479455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08382753548800043,"score_gpt":0.3400401185333519,"score_spread":0.2562125830453515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}