{"id":"W2015674852","doi":"10.1016/j.tig.2006.05.008","title":"To be or not to be toxic: aggregations in Huntington and Alzheimer disease","year":2006,"lang":"en","type":"article","venue":"Trends in Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"","keywords":"Disease; Huntington's disease; Biology; Protein aggregation; Alzheimer's disease; Neurodegeneration; Pathology; Neuroscience; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006929166,0.000217648,0.0001740504,0.0004820054,0.00007985134,0.00007564697,0.0002465916,0.00003960832,0.0001131228],"category_scores_gemma":[0.0002979008,0.0002132192,0.00003574665,0.001079239,0.00007756731,0.00004531759,0.0001848412,0.00009109669,0.00001764859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002986135,"about_ca_system_score_gemma":0.00005901683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005477728,"about_ca_topic_score_gemma":0.001823035,"domain_scores_codex":[0.9981623,0.0001264372,0.0003279381,0.0006615078,0.0003166541,0.0004051643],"domain_scores_gemma":[0.9991022,0.0001345524,0.00004922746,0.0004012293,0.00002750786,0.0002852757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006214781,0.001261548,0.1014418,0.00002727884,0.000007681236,0.000214637,0.002112034,0.05916021,0.7635351,0.001219723,0.009803534,0.06059496],"study_design_scores_gemma":[0.0004374709,0.0001182061,0.4268823,0.00001441907,0.00002466957,0.000001408835,0.00003240822,0.000758725,0.5673763,0.00008193071,0.003993662,0.0002784916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936939,0.0001077491,0.00003895726,0.005032399,0.0001245649,0.0002740436,0.0001414961,0.00003361697,0.0005532044],"genre_scores_gemma":[0.9909685,0.00002701106,0.001812664,0.005719094,0.00007000686,0.00007501836,0.00001115318,0.00003490454,0.001281633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3254406,"threshold_uncertainty_score":0.8694825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08382753548800043,"score_gpt":0.3400401185333519,"score_spread":0.2562125830453515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}