{"id":"W2015691327","doi":"10.1128/jb.182.18.5082-5090.2000","title":"Sequential Inactivation of <i>rdxA</i> (HP0954) and <i>frxA</i> (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in <i>Helicobacter pylori</i>","year":2000,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; National Institutes of Health","keywords":"Nitroreductase; Biology; Helicobacter pylori; Metronidazole; Gene; Microbiology; Genetics; Operon; Antibiotics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365907,0.0003968087,0.0002527931,0.0001283525,0.00009344316,0.0002011416,0.000273039,0.0003149084,0.0008056191],"category_scores_gemma":[0.0002589999,0.0001815076,0.0003111339,0.0001172797,0.0002273111,0.0001113458,0.0002341724,0.0004470135,0.0002824969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002080846,"about_ca_system_score_gemma":0.0001020312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007557793,"about_ca_topic_score_gemma":0.0007709405,"domain_scores_codex":[0.9997261,0.00004624235,0.00003913594,0.00007651405,0.00006046909,0.00005164821],"domain_scores_gemma":[0.9997652,0.00005825663,0.00009854297,0.00003679642,0.00001339271,0.00002784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009493496,0.00003752565,0.0005194484,0.00001257766,0.000007901079,0.00004438692,0.00001045517,0.00003205866,0.9984183,0.00001803809,0.00001787535,0.000786535],"study_design_scores_gemma":[0.00002075839,0.0009489324,0.01684636,0.000005534859,0.00003000578,0.0007800898,0.00003614993,0.0006260738,0.9798517,0.00001666452,0.0008307687,0.000006979996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978918,0.0002559162,0.001208032,0.00003162174,0.00001035327,0.00002113981,0.0001411208,0.00004756144,0.0003924539],"genre_scores_gemma":[0.9971283,0.0001625737,0.001575098,0.00005126846,0.000006160209,0.00002402815,0.0004077263,0.00003368212,0.0006111421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008056191,"threshold_uncertainty_score":0.002695084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0209959966104502,"score_gpt":0.2555618025417174,"score_spread":0.2345658059312672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}