{"id":"W2015691327","doi":"10.1128/jb.182.18.5082-5090.2000","title":"Sequential Inactivation of <i>rdxA</i> (HP0954) and <i>frxA</i> (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in <i>Helicobacter pylori</i>","year":2000,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; National Institutes of Health","keywords":"Nitroreductase; Biology; Helicobacter pylori; Metronidazole; Gene; Microbiology; Genetics; Operon; Antibiotics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004506247,0.0003219022,0.001129632,0.0003951437,0.00007531612,0.00001978219,0.0001167131,0.0002515377,0.000062775],"category_scores_gemma":[0.0001142688,0.0002718289,0.00009038553,0.0002446107,0.0004918089,0.0003927652,0.00007158823,0.0005788516,0.00000280494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000127829,"about_ca_system_score_gemma":0.000138237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001446955,"about_ca_topic_score_gemma":0.0002482251,"domain_scores_codex":[0.9975788,0.0002777926,0.001152609,0.0003413414,0.0002039504,0.0004455061],"domain_scores_gemma":[0.9985001,0.0001414303,0.0005953146,0.0002305622,0.0003518746,0.0001806923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02435081,0.0005916753,0.3009379,0.0002981132,0.001504333,0.0005071997,0.001641437,0.00005676016,0.6584365,0.000140575,0.0008607278,0.010674],"study_design_scores_gemma":[0.01132583,0.002179666,0.9200345,0.0004354304,0.0005494215,0.001889238,0.0002897808,0.0000268815,0.057749,0.0004911879,0.004681119,0.0003479659],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942001,0.002193724,0.00005363082,0.002884827,0.0002717161,0.0002115747,0.00006139561,0.00001285499,0.0001102256],"genre_scores_gemma":[0.9925501,0.004208379,0.001936558,0.0008474136,0.0002576148,0.000009247367,0.00002100414,0.00003348868,0.0001361616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6190966,"threshold_uncertainty_score":0.9999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0209959966104502,"score_gpt":0.2555618025417174,"score_spread":0.2345658059312672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}