{"id":"W2015705139","doi":"10.1038/labinvest.2008.75","title":"The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis","year":2008,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":195,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"China Scholarship Council; Eidgenössische Technische Hochschule Zürich; Deutsche Forschungsgemeinschaft; Shandong University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Hepatotoxin; Fibrosis; Liver injury; Cirrhosis; Toxin; Inflammation; Transcription factor; Steatosis; Detoxification (alternative medicine); Medicine; Knockout mouse; Cancer research; Biology; Immunology; Pharmacology; Pathology; Internal medicine; Toxicity; Gene; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003213057,0.0004801881,0.0004227756,0.0005162177,0.0002522805,0.0002891441,0.0001736353,0.0003780767,0.002890955],"category_scores_gemma":[0.0003232789,0.000157273,0.0002685077,0.0001712131,0.0003601697,0.0005007751,0.0002325912,0.0004492287,0.0003860689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002627804,"about_ca_system_score_gemma":0.0004852694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003896285,"about_ca_topic_score_gemma":0.0007253123,"domain_scores_codex":[0.9998821,0.00003286612,0.000008158903,0.0000183239,0.00002450591,0.00003404186],"domain_scores_gemma":[0.9997604,0.00002077337,0.00006477074,0.00004548967,0.00004031276,0.00006833369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002483435,0.000171029,0.000561796,0.00004733316,0.00002354381,0.00008335814,0.00001719563,0.00006001864,0.9918379,0.0002041976,0.000131907,0.004378258],"study_design_scores_gemma":[0.0001283617,0.002020504,0.005380847,0.00001489982,0.00004761607,0.000560142,0.0000491277,0.0005060747,0.989169,0.0001999674,0.001913197,0.00001023649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928643,0.002043328,0.002849023,0.0003980719,0.00005832785,0.00002773022,0.000236285,0.0001207995,0.001402164],"genre_scores_gemma":[0.9925812,0.0008849647,0.00209953,0.00007407874,0.0000307908,0.00002434917,0.0003426002,0.00001765584,0.00394482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002890955,"threshold_uncertainty_score":0.009671152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1363405124419441,"score_gpt":0.350875754641005,"score_spread":0.2145352421990609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}