{"id":"W2015708711","doi":"10.1038/ncomms6116","title":"Optical control of insulin release using a photoswitchable sulfonylurea","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Studienstiftung des Deutschen Volkes; European Foundation for the Study of Diabetes; Medical Research Council; Diabetes UK; Wellcome Trust","keywords":"Sulfonylurea; Hypoglycemia; Insulin; Sulfonylurea receptor; Beta cell; Potassium channel; Type 2 Diabetes Mellitus; Diabetes mellitus; Endocrinology; Internal medicine; Medicine; Type 2 diabetes; Glucose homeostasis; Pharmacology; Chemistry; Insulin resistance; Islet; Glibenclamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103855,0.0002188768,0.0001091525,0.00009623181,0.0001319995,0.0002742731,0.000299215,0.0002515657,0.0006471635],"category_scores_gemma":[0.0001054532,0.00008835379,0.0001707778,0.00008932761,0.0002911124,0.0001954399,0.0001522469,0.0004183697,0.0001556598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003091985,"about_ca_system_score_gemma":0.0001468655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006558389,"about_ca_topic_score_gemma":0.0007149561,"domain_scores_codex":[0.999931,0.000004656107,0.000003882429,0.0000251392,0.00002123448,0.00001410846],"domain_scores_gemma":[0.9999384,0.00001292416,0.00002223864,0.000005569165,0.00000602156,0.00001473191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003650564,0.00001224767,0.00004395038,0.00002299533,0.000002388325,0.00003111738,0.00001095015,0.0001055984,0.9976991,0.0002863354,0.00004729472,0.001701603],"study_design_scores_gemma":[0.000007671699,0.0001101061,0.0002394137,0.000002359657,0.000003552437,0.00004046869,0.000007222072,0.0009075127,0.9971952,0.00005482206,0.001427028,0.000004489511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713055,0.001684873,0.02034503,0.0001916953,0.0001050587,0.00003918556,0.0002029075,0.0003552633,0.00577055],"genre_scores_gemma":[0.9914218,0.0006918281,0.005317341,0.0001131399,0.00001052001,0.00002169864,0.00007463942,0.00002868892,0.002320342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006558389,"threshold_uncertainty_score":0.0022434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05214594648124452,"score_gpt":0.3535722946855006,"score_spread":0.3014263482042561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}