{"id":"W2015735089","doi":"10.1038/sj.onc.1205890","title":"Hypomethylation and hypermethylation of DNA in Wilms tumors","year":2002,"lang":"en","type":"article","venue":"Oncogene","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute; National Institutes of Health","keywords":"DNA methylation; Biology; CpG site; Methylation; Carcinogenesis; Methyltransferase; Wilms' tumor; Cancer research; DNMT1; Molecular biology; genomic DNA; Bisulfite sequencing; DNA methyltransferase; DNA; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002126693,0.000161426,0.0002025181,0.001456519,0.0001932548,0.0002408157,0.000160306,0.0001963529,0.001240822],"category_scores_gemma":[0.0004656567,0.0001475126,0.0001119408,0.0004358908,0.0002471845,0.0001741704,0.0001554343,0.0002355748,0.0001695974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002087061,"about_ca_system_score_gemma":0.000221147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001392922,"about_ca_topic_score_gemma":0.00108781,"domain_scores_codex":[0.9999131,0.0000174458,0.000009285749,0.0000197737,0.00002470577,0.00001566983],"domain_scores_gemma":[0.999811,0.00004614504,0.00005012289,0.00001474125,0.00003047413,0.00004741374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001345266,0.00002756248,0.05208044,0.00008950571,0.0000608974,0.0006296126,0.0002310504,0.0002796969,0.9349504,0.0005112567,0.0002052757,0.009588962],"study_design_scores_gemma":[0.00004816263,0.0002635803,0.6005129,0.00001200998,0.0001457764,0.005122385,0.0002711337,0.0008842886,0.3883376,0.00099337,0.003394298,0.00001457022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957558,0.001846788,0.0009525228,0.00007672459,0.000008518346,0.000004240406,0.0003211678,0.00004203311,0.0009922752],"genre_scores_gemma":[0.9981709,0.0005449723,0.0002747179,0.00001734781,0.00001167968,0.000004513631,0.0002414658,0.000007884994,0.0007265483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456519,"threshold_uncertainty_score":0.004150927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020824983466389,"score_gpt":0.2202786741443205,"score_spread":0.2100704243096566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}