{"id":"W2015735089","doi":"10.1038/sj.onc.1205890","title":"Hypomethylation and hypermethylation of DNA in Wilms tumors","year":2002,"lang":"en","type":"article","venue":"Oncogene","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute; National Institutes of Health","keywords":"DNA methylation; Biology; CpG site; Methylation; Carcinogenesis; Methyltransferase; Wilms' tumor; Cancer research; DNMT1; Molecular biology; genomic DNA; Bisulfite sequencing; DNA methyltransferase; DNA; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006321276,0.0000507624,0.00007118634,0.00004132509,0.00001265379,0.000002424031,0.00003006834,0.00007736862,0.00001698589],"category_scores_gemma":[0.00001857001,0.00004482231,0.00002126037,0.00009110594,0.00003378182,0.000002204119,0.00001482875,0.00003241439,0.000002429225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007169152,"about_ca_system_score_gemma":0.000007385635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002192434,"about_ca_topic_score_gemma":0.00001217817,"domain_scores_codex":[0.9996235,0.00002060925,0.0001158186,0.0001154624,0.00005260035,0.0000719482],"domain_scores_gemma":[0.9998353,0.000004492237,0.00004464759,0.00007395403,0.00001738252,0.00002428208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001394349,0.00001760094,0.003872373,0.000007898062,0.000008933183,0.00000107076,0.00004126193,0.0002137989,0.9700706,0.00001297675,0.00007113815,0.02566841],"study_design_scores_gemma":[0.0006045906,0.0001996802,0.01085555,0.0000226481,0.000008629774,0.00001073753,0.00002496779,0.0006189957,0.9835547,0.00009995247,0.003891059,0.0001084381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936127,0.002895322,0.00005353357,0.00006371291,0.000035549,0.00005180923,0.000002511169,0.000002262376,0.003282618],"genre_scores_gemma":[0.9981138,0.0011407,0.0002146721,0.0000314572,0.00004095863,0.000003123497,0.00001393243,0.000005750756,0.0004356424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02555997,"threshold_uncertainty_score":0.1827801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020824983466389,"score_gpt":0.2202786741443205,"score_spread":0.2100704243096566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}