{"id":"W2015745313","doi":"10.1074/jbc.m110.140905","title":"Degradation of the Human Mitotic Checkpoint Kinase Mps1 Is Cell Cycle-regulated by APC-cCdc20 and APC-cCdh1 Ubiquitin Ligases*","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Program for New Century Excellent Talents in University; York University; National Natural Science Foundation of China; U.S. Department of Defense","keywords":"Anaphase-promoting complex; CDC20; Mitotic exit; Cell biology; Mitosis; Spindle checkpoint; Ubiquitin ligase; Biology; Cell division control protein 4; Centrosome; Cell cycle; MG132; Proteasome; Cell cycle checkpoint; Ubiquitin; Anaphase; Chemistry; Spindle apparatus; Cell division; Proteasome inhibitor; Cell; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009908174,0.0003144146,0.0002389961,0.0002301733,0.0001987127,0.0003906329,0.0001205533,0.0001936326,0.0007239481],"category_scores_gemma":[0.00009743552,0.0001706984,0.0002168823,0.000130169,0.0001300122,0.0001193759,0.0001831946,0.0001988031,0.0004037661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006528171,"about_ca_system_score_gemma":0.0002441567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001095425,"about_ca_topic_score_gemma":0.001511014,"domain_scores_codex":[0.9999013,0.000008451608,0.00001290066,0.00003474375,0.00002080318,0.00002171974],"domain_scores_gemma":[0.9999326,0.000009134566,0.00002381993,0.000006977721,0.000009037114,0.00001835085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001081691,0.00001422673,0.0005225664,0.00004849852,0.000007467468,0.00007090093,0.000007118498,0.00006678877,0.9973827,0.00006450335,0.00008835072,0.001618624],"study_design_scores_gemma":[0.00001543456,0.00008884187,0.02064022,0.000005316287,0.00001462728,0.0004294846,0.00001546692,0.001587193,0.973177,0.00004020289,0.00398102,0.00000532637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905326,0.006027361,0.001619779,0.00009957037,0.00002529981,0.00002732954,0.0007162844,0.00007128002,0.0008804296],"genre_scores_gemma":[0.9926864,0.001579166,0.001320297,0.00007786617,0.00001235302,0.00003345844,0.00130341,0.00001922495,0.0029679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001095425,"threshold_uncertainty_score":0.004736543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007169672355127137,"score_gpt":0.2234189469572279,"score_spread":0.2162492746021007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}