{"id":"W2015748323","doi":"10.1016/j.nbd.2005.07.005","title":"Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome","year":2005,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":337,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institutes of Health; University of California, Davis; Heart and Stroke Foundation of Canada; International Rett Syndrome Foundation; Foundation for the National Institutes of Health","keywords":"Rett syndrome; MECP2; Neuroscience; Synaptic plasticity; Hippocampal formation; Psychology; Hippocampus; Neuroplasticity; Biology; Medicine; Internal medicine; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000882337,0.0001663156,0.0001953253,0.00005725118,0.00003203168,0.000003452461,0.0003518921,0.00009865685,0.00001717339],"category_scores_gemma":[0.00008303971,0.0001358235,0.0001017134,0.00009239965,0.0002146184,0.000003108504,0.0001136831,0.00009520436,0.000004666978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005520019,"about_ca_system_score_gemma":0.0001078362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006709159,"about_ca_topic_score_gemma":0.00002309524,"domain_scores_codex":[0.9989074,0.0001103484,0.00031528,0.0003306622,0.00009648207,0.0002398576],"domain_scores_gemma":[0.999428,0.00002657323,0.0001103801,0.0003103192,0.00004457149,0.00008015242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004775305,0.0005274118,0.008200339,0.00005341687,0.00004989079,0.000002385033,0.00015694,0.005650628,0.9835713,0.00005944068,0.001035029,0.0002156974],"study_design_scores_gemma":[0.004012652,0.002483597,0.3831883,0.00004702303,0.0001995276,0.00002050194,0.0001998812,0.01001757,0.5974739,0.0009957429,0.0004551232,0.0009061698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987578,0.0001149301,0.00007576848,0.0005390475,0.00002913331,0.0002164239,0.0001821559,0.000005039336,0.00007968272],"genre_scores_gemma":[0.9985328,0.0001439838,0.0001447257,0.001040814,0.000007263895,0.00001806733,0.00004815724,0.00001602913,0.00004814373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3860974,"threshold_uncertainty_score":0.5538723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01142432138216913,"score_gpt":0.2194753543355517,"score_spread":0.2080510329533826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}