{"id":"W2015761210","doi":"10.1021/bi034293v","title":"Family 39 α-l-Iduronidases and β-d-Xylosidases React through Similar Glycosyl−Enzyme Intermediates: Identification of the Human Iduronidase Nucleophile","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Studies on Chitinases and Chitosanases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Nucleophile; Glycoside hydrolase; Stereochemistry; Enzyme; Glycosyl; Active site; Substrate (aquarium); Peptide sequence; Biochemistry; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001881595,0.0002724371,0.0001473317,0.0001712948,0.0001462743,0.0002292825,0.0001403533,0.0002859178,0.001024409],"category_scores_gemma":[0.0001669475,0.0001234235,0.000312583,0.0001195338,0.0001917413,0.0002494462,0.0001709965,0.0002544825,0.0005296223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002212988,"about_ca_system_score_gemma":0.0001886235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007095858,"about_ca_topic_score_gemma":0.0004671599,"domain_scores_codex":[0.9999042,0.00001357825,0.000007396122,0.00003230223,0.00002171442,0.00002087443],"domain_scores_gemma":[0.9998981,0.00001019671,0.00003431071,0.0000115221,0.00002091551,0.00002502826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001053927,0.0000121862,0.001623997,0.00002450475,0.000008565621,0.0002206061,0.00003234334,0.00005837596,0.9936103,0.0001218818,0.00004492009,0.00413693],"study_design_scores_gemma":[0.00001531119,0.0003179869,0.01452874,0.000009397233,0.00001881883,0.002456446,0.00005744021,0.0005483057,0.9767306,0.0001416437,0.005168063,0.00000720981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887109,0.002541444,0.005613168,0.00008005098,0.00001495703,0.00003917229,0.0001584574,0.00005268952,0.002789127],"genre_scores_gemma":[0.987954,0.001271252,0.006725987,0.00006942206,0.000009920735,0.00002948561,0.0007313746,0.00001213989,0.003196369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024409,"threshold_uncertainty_score":0.003426969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165625483645555,"score_gpt":0.2457337251418686,"score_spread":0.234077470305413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}