{"id":"W2015761210","doi":"10.1021/bi034293v","title":"Family 39 α-<scp>l</scp>-Iduronidases and β-<scp>d</scp>-Xylosidases React through Similar Glycosyl−Enzyme Intermediates:  Identification of the Human Iduronidase Nucleophile","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Studies on Chitinases and Chitosanases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Nucleophile; Glycoside hydrolase; Stereochemistry; Enzyme; Glycosyl; Active site; Substrate (aquarium); Peptide sequence; Biochemistry; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000210681,0.0004871131,0.0003895113,0.00003604635,0.0004171189,0.00008158486,0.0005349856,0.0003170643,0.000009239101],"category_scores_gemma":[0.002316412,0.0004151388,0.0002908009,0.0002114753,0.0006445884,0.00001799665,0.0003754331,0.0002211551,0.000006449388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003464744,"about_ca_system_score_gemma":0.0001311542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003839081,"about_ca_topic_score_gemma":0.00001796197,"domain_scores_codex":[0.9974744,0.0001129755,0.0006601776,0.0008302959,0.0003424593,0.0005796378],"domain_scores_gemma":[0.9978771,0.0002354748,0.0005192932,0.001051091,0.0001646234,0.0001523922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006548922,0.0002614296,0.006231882,0.0001998671,0.0001422763,0.000006711905,0.0001557028,0.000007130801,0.9728003,0.0001414161,0.01997963,0.00006716041],"study_design_scores_gemma":[0.0006916721,0.0001592099,0.01319802,0.000106497,0.0001182413,0.00003417236,0.002952261,0.000005909804,0.9633901,0.0002324535,0.01897176,0.0001397287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858757,0.008467483,0.00003149273,0.00005032552,0.0002377263,0.0002979595,0.000411342,0.00004117483,0.004586842],"genre_scores_gemma":[0.996434,0.001199105,0.00009444046,0.0003852172,0.0003302693,0.00005688981,0.0002531914,0.00006644017,0.001180501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01055829,"threshold_uncertainty_score":0.9998301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165625483645555,"score_gpt":0.2457337251418686,"score_spread":0.234077470305413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}