{"id":"W2015772815","doi":"10.1021/bi8008664","title":"Repair of <i>O</i><sup>6</sup>-G-Alkyl-<i>O</i><sup>6</sup>-G Interstrand Cross-Links by Human <i>O</i><sup>6</sup>-Alkylguanine-DNA Alkyltransferase","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"DNA; Guanine; Chemistry; DNA repair; Stereochemistry; Mutagenesis; Dimer; DNA damage; Nucleotide; Biochemistry; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0009811332,0.001938932,0.001665728,0.0002400062,0.000809686,0.0001499846,0.002079957,0.002788462,0.000556598],"category_scores_gemma":[0.0004307276,0.002119121,0.00181314,0.0007083353,0.001719875,0.00008923248,0.0007352944,0.001564094,0.0001111821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000213459,"about_ca_system_score_gemma":0.0006693235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001791004,"about_ca_topic_score_gemma":0.000007177409,"domain_scores_codex":[0.990415,0.0003075516,0.00246132,0.003213379,0.001432944,0.002169831],"domain_scores_gemma":[0.9938008,0.000128795,0.0006405822,0.003564774,0.0007261463,0.001138953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008146203,0.0008300035,0.003735507,0.0006661422,0.0007635527,0.0002181776,0.0008702275,0.001070022,0.9422556,0.00005900379,0.04830675,0.000410423],"study_design_scores_gemma":[0.005272187,0.001074296,0.00006641871,0.0002567515,0.000258195,0.0006618071,0.0008243381,0.001961311,0.9420739,0.00006514313,0.04537899,0.002106711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986704,0.003687022,0.0007609929,0.0002035128,0.0001852859,0.001069485,0.001750935,0.0005931096,0.005045682],"genre_scores_gemma":[0.9819584,0.0008606766,0.001816024,0.001081358,0.001412856,0.000223066,0.003585842,0.0004368542,0.00862492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00474557,"threshold_uncertainty_score":0.9993354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009897031840489543,"score_gpt":0.2448778864188811,"score_spread":0.2349808545783916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}