{"id":"W2015780669","doi":"10.1158/0008-5472.can-06-3235","title":"IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth <i>In vivo</i>","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":218,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Angiogenesis; Biology; Signal transduction; Vascular endothelial growth factor; Cell biology; Vascular endothelial growth factor A; Unfolded protein response; Cancer research; Hypoxia-inducible factors; Hypoxia (environmental); Endoplasmic reticulum; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004577186,0.0001626357,0.0001936309,0.0001371935,0.0001555944,0.00006324982,0.000148453,0.0001193093,0.00002587573],"category_scores_gemma":[0.0003335868,0.000148134,0.0000792283,0.000158616,0.00009683498,0.000008666045,0.0001813123,0.0001001518,8.635282e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003492361,"about_ca_system_score_gemma":0.000113967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003227352,"about_ca_topic_score_gemma":0.00005809879,"domain_scores_codex":[0.9983903,0.00005800621,0.0002026854,0.0005466674,0.000255329,0.0005469756],"domain_scores_gemma":[0.9991299,0.0001273614,0.00003407349,0.0001729576,0.0002639427,0.0002717936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005365659,0.00003606333,0.01403127,0.0001222516,0.00003442234,0.000009970267,0.00007332746,0.000001443683,0.983698,0.00005086822,0.001114405,0.000291427],"study_design_scores_gemma":[0.001651086,0.0001213929,0.001229889,0.00008732206,0.0000141389,0.000001721383,0.0001293802,0.00001040918,0.9946123,0.0001009628,0.001866417,0.0001750116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947221,0.003257258,0.0008274408,0.0001964154,0.00006491181,0.0005885727,0.0002575932,0.000006961257,0.0000787103],"genre_scores_gemma":[0.9984115,0.0005868197,0.0001886898,0.0002314995,0.0002664407,0.000197701,0.00001571195,0.00002933135,0.00007227078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01280138,"threshold_uncertainty_score":0.604073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081380386750536,"score_gpt":0.3313516516987955,"score_spread":0.3105378478312901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}