{"id":"W2015818551","doi":"10.1046/j.1365-2958.2000.01671.x","title":"Isolation of the <i>topB</i> gene encoding DNA topoisomerase III as a multicopy suppressor of <i>topA</i> null mutations in <i>Escherichia coli</i>","year":2000,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Medical Research Council Canada","keywords":"Biology; Topoisomerase; DNA supercoil; Molecular biology; Transcription (linguistics); Mutant; Gene; DNA; RNase P; RNA; RNase H; Genetics; DNA replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193822,0.0005043273,0.0003349699,0.0002920041,0.0001568199,0.0003860218,0.0004052441,0.0003337532,0.0005541692],"category_scores_gemma":[0.0001822896,0.0002492159,0.0003850322,0.0002470594,0.0002500394,0.0001205357,0.0003280659,0.0007332957,0.0006064955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002692393,"about_ca_system_score_gemma":0.0003164233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001377612,"about_ca_topic_score_gemma":0.00118047,"domain_scores_codex":[0.9998324,0.00002318934,0.00001936792,0.00003179738,0.00006226354,0.00003103474],"domain_scores_gemma":[0.999768,0.00004812472,0.00006196449,0.00003503462,0.00002350357,0.00006338314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001232727,0.000008857473,0.00008232215,0.00001055364,0.000001767396,0.00002326356,0.00000365437,0.00001740577,0.9995717,0.00002179889,0.000009606055,0.0002367461],"study_design_scores_gemma":[0.00001312143,0.0001019892,0.004539008,0.000009336949,0.00002263116,0.0004110934,0.00003049826,0.0007598455,0.9924314,0.00002742461,0.001646464,0.00000717042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864438,0.0007720733,0.009819861,0.0002026338,0.00005074136,0.000120645,0.001243215,0.0001363147,0.001210859],"genre_scores_gemma":[0.9773725,0.0006265243,0.01509282,0.0001361858,0.00002029335,0.00008024387,0.003049569,0.0001524454,0.003469454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377612,"threshold_uncertainty_score":0.002739131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005398923497190278,"score_gpt":0.2260150690335358,"score_spread":0.2206161455363455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}