{"id":"W2015820044","doi":"10.1021/bi0007728","title":"Specificity and Affinity of Substrate Binding by a Family 17 Carbohydrate-Binding Module from <i>Clostridium cellulovorans</i> Cellulase 5A","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Polysaccharides and Plant Cell Walls","field":"Agricultural and Biological Sciences","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Carbohydrate-binding module; Cellulase; Chemistry; Tryptophan; Binding site; Ligand (biochemistry); Stereochemistry; Quenching (fluorescence); Biochemistry; Cellulose; Affinities; Fluorescence; Amino acid; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001225744,0.0002298225,0.0002971506,0.000006874418,0.0001455212,0.00007255195,0.0002509019,0.0002089021,0.001352513],"category_scores_gemma":[0.000005024479,0.0001191701,0.0001178102,0.0001904339,0.00009296427,0.00006876809,0.00003969633,0.0001696611,0.00002948483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001868341,"about_ca_system_score_gemma":0.00001235438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002038798,"about_ca_topic_score_gemma":0.00003886866,"domain_scores_codex":[0.9987057,0.00002965463,0.0002925577,0.0004418915,0.0001922094,0.0003379123],"domain_scores_gemma":[0.9994372,0.0001327696,0.0001214653,0.00009876267,0.00002216552,0.0001875977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004562319,0.00007486871,0.001065273,0.00001408485,0.000043289,0.0000113569,0.00002047587,0.000001851914,0.9961206,7.189644e-7,0.001733187,0.0008687071],"study_design_scores_gemma":[0.0001375812,0.00003573678,0.0008081475,0.00002383247,0.00007402026,0.000002349736,0.0001057476,0.00005555713,0.9969292,0.00002145255,0.00154775,0.0002585668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928728,0.001149522,4.600233e-7,0.00009051729,0.00004578722,0.0000959586,0.003505452,0.00004269815,0.002196837],"genre_scores_gemma":[0.9970083,0.0004120981,0.00003900777,0.00004023361,0.0001527094,0.000003107142,0.0007446567,0.000002113361,0.001597727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004135579,"threshold_uncertainty_score":0.9995604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217976644171536,"score_gpt":0.1781799169106523,"score_spread":0.1660001504689369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}