{"id":"W2015827186","doi":"10.1038/modpathol.3880292","title":"Carcinogenesis in the GI Tract: From Morphology to Genetics and Back Again","year":2001,"lang":"en","type":"review","venue":"Modern Pathology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Microsatellite instability; MLH1; MSH2; DNA mismatch repair; Genome instability; Chromosome instability; Biology; Carcinogenesis; Colorectal cancer; Genetics; Cancer; Cancer research; Microsatellite; Lynch syndrome; Gene; Allele; DNA; DNA damage; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008404191,0.001221516,0.002026162,0.002743526,0.0003485983,0.001287929,0.001087263,0.001867428,0.002131284],"category_scores_gemma":[0.001144335,0.0003670402,0.0005155244,0.003399901,0.001207949,0.002484423,0.0007402358,0.00223513,0.00143771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008296508,"about_ca_system_score_gemma":0.001395049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00205375,"about_ca_topic_score_gemma":0.003377938,"domain_scores_codex":[0.9997539,0.00005187732,0.00003636405,0.00004931754,0.00008865963,0.0000199077],"domain_scores_gemma":[0.999186,0.0004370785,0.00007950584,0.00002777617,0.0002058768,0.00006383504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001051692,0.00006652639,0.000635036,0.01422389,0.0001024175,0.0008082576,0.00009874738,0.0006536879,0.002497375,0.003699317,0.03721033,0.9398993],"study_design_scores_gemma":[0.00002741709,0.00009662787,0.00199516,0.003618378,0.0001463343,0.005078893,0.0001800243,0.0001358964,0.0005370343,0.003615211,0.9845312,0.00003787215],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007258204,0.9987011,0.0001443609,0.0003535556,0.0002736215,0.000001391321,0.000004833998,0.00000465156,0.000443797],"genre_scores_gemma":[0.0003983368,0.9985239,0.0001591793,0.0002041899,0.0003601874,0.000001614918,0.000007413476,7.512429e-7,0.0003443527],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002743526,"threshold_uncertainty_score":0.007129848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08716406604264278,"score_gpt":0.3453007206514801,"score_spread":0.2581366546088373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}