{"id":"W2015827186","doi":"10.1038/modpathol.3880292","title":"Carcinogenesis in the GI Tract: From Morphology to Genetics and Back Again","year":2001,"lang":"en","type":"review","venue":"Modern Pathology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Microsatellite instability; MLH1; MSH2; DNA mismatch repair; Genome instability; Chromosome instability; Biology; Carcinogenesis; Colorectal cancer; Genetics; Cancer; Cancer research; Microsatellite; Lynch syndrome; Gene; Allele; DNA; DNA damage; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003744399,0.0005230609,0.001968672,0.0002860069,0.00003811006,0.0000158613,0.0004044342,0.0008899732,0.0003182848],"category_scores_gemma":[0.0001208007,0.0003674624,0.0002223198,0.0003432763,0.000178987,0.00001018346,0.0001921175,0.0006625201,0.0002303019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667489,"about_ca_system_score_gemma":0.0002258986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001136139,"about_ca_topic_score_gemma":0.000181686,"domain_scores_codex":[0.9970178,0.0005845862,0.0006643282,0.0009496072,0.0002312514,0.0005524045],"domain_scores_gemma":[0.9982224,0.0004312096,0.0001637561,0.0009786257,0.00004567327,0.0001583066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003260382,0.0001131751,0.002608349,0.0009556055,0.00004427696,0.002104491,0.0009864512,0.00001062341,0.0001479263,0.00000230415,0.000599026,0.9923952],"study_design_scores_gemma":[0.000788475,0.0007073747,0.01239,0.001180583,0.001133361,0.005374453,0.00004984784,0.00005006511,0.00001879447,0.0004313271,0.9773117,0.0005640427],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09459667,0.9020606,0.0002554501,0.0003523846,0.0003528307,0.001478611,0.0001314387,0.00001758928,0.0007544531],"genre_scores_gemma":[0.006181402,0.9892871,0.001421464,0.001901585,0.0003094013,0.0003213806,0.0001443656,0.0000993246,0.0003339734],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9918311,"threshold_uncertainty_score":0.9998778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08716406604264278,"score_gpt":0.3453007206514801,"score_spread":0.2581366546088373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}