{"id":"W2015831230","doi":"10.1038/nmeth.1939","title":"Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures","year":2012,"lang":"en","type":"article","venue":"Nature Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Induced pluripotent stem cell; Cell biology; Germ layer; Biology; Cellular differentiation; Embryonic stem cell; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007596637,0.0003516216,0.0004548214,0.0006533163,0.0005503419,0.001097539,0.0008774779,0.0005060539,0.002804604],"category_scores_gemma":[0.0004500092,0.0004023492,0.0004250349,0.0007805236,0.0003743439,0.0004361826,0.0006210944,0.001629546,0.003660425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552022,"about_ca_system_score_gemma":0.0004683209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004350782,"about_ca_topic_score_gemma":0.001084295,"domain_scores_codex":[0.9993697,0.00006892964,0.0001212181,0.0001287042,0.0002515786,0.00005994819],"domain_scores_gemma":[0.9995244,0.0001144827,0.00004685654,0.0001283556,0.00011557,0.0000704065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006297407,0.00004890525,0.0003273774,0.0000784341,0.000008188741,0.0001052347,0.0000791804,0.0001660893,0.9922606,0.0007614261,0.0004633448,0.005638335],"study_design_scores_gemma":[0.00003486641,0.0002018767,0.002269509,0.00003365771,0.00004846737,0.0002853246,0.00004697758,0.001692956,0.9680548,0.0004207043,0.02689657,0.00001424552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4993744,0.008073851,0.4224019,0.0008756117,0.0009638639,0.0032978,0.02415799,0.002319303,0.03853521],"genre_scores_gemma":[0.6269088,0.007388544,0.286916,0.0005826062,0.0002835717,0.002567648,0.02442247,0.0009543144,0.04997599],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002804604,"threshold_uncertainty_score":0.009382367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026904415051737,"score_gpt":0.3428342031285022,"score_spread":0.3225651589779848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}