{"id":"W2015849111","doi":"10.1126/science.1099870","title":"Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol","year":2004,"lang":"en","type":"article","venue":"Science","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":1110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute","keywords":"Nonsynonymous substitution; Genetics; Biology; Allele; Population; Phenotype; Gene; Medicine; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004065638,0.0001196339,0.0002815908,0.0001670492,0.00009384545,0.00002863452,0.0002899086,0.00004962701,0.00002895227],"category_scores_gemma":[0.0005090343,0.00009421455,0.00005904297,0.0005639617,0.000338604,0.0002025633,0.0001033722,0.0001193772,0.00008974811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005465829,"about_ca_system_score_gemma":0.0002762998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005047648,"about_ca_topic_score_gemma":0.00005801833,"domain_scores_codex":[0.9984892,0.00001053896,0.0002396852,0.0003389526,0.0005543882,0.0003672405],"domain_scores_gemma":[0.9989761,0.00003119908,0.00006640296,0.0003774457,0.0002210725,0.0003278213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001160299,0.0002031137,0.00909362,0.00006384211,0.00001126947,0.00001473149,0.001854843,0.0005677716,0.9624184,0.0002500339,0.00009896142,0.02530732],"study_design_scores_gemma":[0.003780088,0.0001746908,0.6260199,0.0002195365,0.00001682687,0.0000436354,0.0001402867,0.0001095481,0.3595633,0.00005917417,0.009750417,0.0001226161],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965255,0.00006815309,0.0005571977,0.001715373,0.0004263278,0.000344152,0.00005019026,0.00003790615,0.0002752395],"genre_scores_gemma":[0.9964859,0.000006806174,0.001799656,0.001148276,0.0001607813,0.00000990141,0.000002128889,0.000008629953,0.0003779063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6169263,"threshold_uncertainty_score":0.3841958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02047959875942979,"score_gpt":0.2784531315948965,"score_spread":0.2579735328354667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}