{"id":"W2015849111","doi":"10.1126/science.1099870","title":"Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol","year":2004,"lang":"en","type":"article","venue":"Science","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":1110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute","keywords":"Nonsynonymous substitution; Genetics; Biology; Allele; Population; Phenotype; Gene; Medicine; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004731339,0.000328516,0.0004620751,0.0008456676,0.0003252401,0.0003313718,0.0002449887,0.0004791282,0.001673583],"category_scores_gemma":[0.002052578,0.0002065144,0.0002449534,0.000386376,0.0004990097,0.0001509019,0.0003549229,0.0004325309,0.000248692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000122671,"about_ca_system_score_gemma":0.0001305854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004658736,"about_ca_topic_score_gemma":0.0004715509,"domain_scores_codex":[0.9995583,0.0001228882,0.00004343976,0.0001314631,0.00009163944,0.00005221348],"domain_scores_gemma":[0.998825,0.0004697433,0.0003195611,0.0001704758,0.0000756197,0.0001395949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001052408,0.0001210797,0.7773248,0.00006610747,0.0003522423,0.004559772,0.0003440735,0.0003499207,0.1888942,0.000615463,0.000225275,0.02609459],"study_design_scores_gemma":[0.00007922362,0.0005474618,0.9636087,0.00001999041,0.0004040896,0.0183473,0.000217001,0.001422036,0.01270121,0.001537024,0.001093711,0.00002220897],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987406,0.0002512411,0.0006040412,0.00005498364,0.000005427693,0.000003147612,0.00003300889,0.0000136567,0.0002938831],"genre_scores_gemma":[0.9992417,0.000105641,0.0003754587,0.00003274898,0.00002401718,0.000002302266,0.00004448793,0.000004210813,0.0001695236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001673583,"threshold_uncertainty_score":0.005598664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02047959875942979,"score_gpt":0.2784531315948965,"score_spread":0.2579735328354667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}